Abstract

As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency.

Keywords: HI-6, Reactivator, Acetylcholinesterase, Cyclosarine, Nerve agent, Salt, Ion exchange, Antidote, Oxime, Quaternary nitrogen