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Letters in Drug Design & Discovery

Author(s): Rupinder K. Lota, Sachin Dhanani, Caroline P. Owen and Sabbir Ahmed

DOI: 10.2174/157018007780077417

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Search for Potential Non-Steroidal Inhibitors of 17 β-Hydroxysteroid Dehydrogenase (17 β-HSD) in the Treatment of Hormone-Dependent Cancers

Page: [180 - 184] Pages: 5

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Abstract

We report the search for non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, for types 1 and 3. The results show that the synthesised compounds based on the biphenyl backbone were good inhibitors of 17β-HSD1, but were weak inhibitors of 17β-HSD3. The compounds were evaluated against 3β-HSD but showed weak inhibition.

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme inhibition, Biphenyl ketones