Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

T.   G.   Tolstikova; A.   O.   Bryzgalov; I.   V.   Sorokina; M.   V.   Hvostov; A.   S.   Ratushnyak; T.   A.   Zapara; O.   G.   Simonova

Letters in Drug Design & Discovery

Author(s): T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara and O. G. Simonova

DOI: 10.2174/157018007780077453

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Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

Page: [168 - 170] Pages: 3

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Abstract

The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.

Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels

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