Generic placeholder image

Letters in Drug Design & Discovery

Author(s): Roy Asaf, Shany Blum, Rachel Miller-Lotan and Andrew P. Levy

DOI: 10.2174/157018007779422479

DownloadDownload PDF Flyer Cite As
BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury

Page: [160 - 162] Pages: 3

  • * (Excluding Mailing and Handling)

Abstract

Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.

Keywords: Diabetes, Myocardial ischemia-reperfusion, Oxidative stress, BXT-51072