Author(s): Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber
Page: [92 - 98] Pages: 7
* (Excluding Mailing and Handling)
We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
Keywords: Gene delivery, Cationic polymer, Transfection
Download PDF Flyer