Letters in Drug Design & Discovery

Author(s): Andre Gustavo Tempone, Marcia de Souza Carvalho Melhem, Frederico Oliveira Prado, Gabriela Motoie, Roberto Mitsuyoshi Hiramoto, Marta Maria Antoniazzi, Celio Fernando Baptista Haddad and Carlos Jared

DOI: 10.2174/157018007778992856

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Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds

Page: [67 - 73] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.

Keywords: Peptides, Secretions, Amphibians, Leishmania, Trypanosoma, Antimicrobial