Abstract

The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.

Keywords: Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide