Author(s): M. Paula M. Marques, Fernanda Borges, Joana Sousa, Rita Calheiros, Jorge Garrido, Alexandra Gaspar, Carmen Diniz and Paula Fresco
Page: [316 - 320] Pages: 5
* (Excluding Mailing and Handling)
The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and antiinflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5- trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5- trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between antiinflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.
Keywords: Hydroxycinnamic derivatives, anti-inflammatory, COX-2, anticancer, mammary gland adenocarcinoma cells
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