Abstract

The therapeutic efficacy of most pharmacological agents is generally established first in rodents and then in humans. To better extrapolate the effects of pharmacological agents in rodents to humans it is important to know how similar (or dissimilar) systems are between rodents and humans. This review examines the differences in the localization of the noradrenergic receptors in the hippocampus of humans and rodents. The differences in receptor localization could have major implications for the actions (or side effects) of noradrenergic agents in humans.

Keywords: Norepinephrine, Adrenoreceptors, Hippocampus, Alpha receptors, Beta receptors