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Letters in Drug Design & Discovery

Author(s): Stefano Moro, Flavia Varano, Giorgio Cozza, Mario A. Pagano, Giuseppe Zagotto, Adriana Chilin, Adriano Guiotto, Daniela Catarzi, Vittoria Calotta and Lorenzo A. Pinna

DOI: 10.2174/157018006776743233

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Pyrazoloquinazoline Tricyclic System as Novel Scaffold to Design New Kinase CK2 Inhibitors

Page: [281 - 284] Pages: 4

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Abstract

Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.

Keywords: Kinase CK2, CK2 inhibitors, virtual screening