Combinatorial Chemistry & High Throughput Screening

Author(s): Maryam Sabbaghan, Mostafa Alidoust and Zinatossadat Hossaini

DOI: 10.2174/138620711796957134

A Rapid, Four-Component Synthesis of Functionalized Thiazoles

Page: [824 - 828] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl)(phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.

Keywords: Thiazole, Hantzsch synthesis, 2-Bromoacethophenone, Aroyl isothiocyanate, Secondary amine, acid chlorides, heterocycle, estrogen receptors, fungicides, drugs