Author(s): S. M. Fiuza, A. M. Amado, Paulo J. Oliveira, Vilma A. Sardao, L. A.E.B. de Carvalho and M. P.M. Marques
Page: [149 - 151] Pages: 3
* (Excluding Mailing and Handling)
Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).
Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma
Download PDF Flyer