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Letters in Drug Design & Discovery

Author(s): A. S. Carvalho, D. Gibaldi, A. C. Pinto, M. Bozza and N. Boechat

DOI: 10.2174/157018006775789667

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Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles

Page: [98 - 101] Pages: 4

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Abstract

A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.

Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity