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Letters in Drug Design & Discovery

Author(s): Hua Lu, Haixia Lin, Yi Jiang, Xinguang Zhou, Beili Wu and Jianmin Chen

DOI: 10.2174/157018006775789757

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Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Page: [83 - 86] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

Keywords: Camptothecin, ester, succinate, prodrug, antitumor