Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Hayamitsu      Adachi; Yoshinori      Takahashi; Motoki      Kyo; Tsuyoshi      Sato; Yoshio      Nishimura

Letters in Drug Design & Discovery

Author(s): Hayamitsu Adachi, Yoshinori Takahashi, Motoki Kyo, Tsuyoshi Sato and Yoshio Nishimura

DOI: 10.2174/157018006775789694

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Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Page: [71 - 75] Pages: 5

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Abstract

Interactions of α-amino or guanidino-α-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

Keywords: Aminoglycoside, surface plasmon resonance imaging, RNA recognition

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