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Combinatorial Chemistry & High Throughput Screening

Author(s): Maryam Sabbaghan, Issa Yavari and Zinatossadat Hossaini

DOI: 10.2174/138620710792927358

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Synthesis of Functionalized Chromenes from Meldrum’s Acid, 4- Hydroxycoumarin, and Ketones or Aldehydes

Page: [813 - 817] Pages: 5

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Abstract

An efficient synthesis of 4-alkyl-4-methyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-dione or 4-aryl-3,4- dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones via reaction 4-hydroxycoumarin with Meldrum’s acid and ketones or aldehydes is described.

Keywords: Chromene, proline, aqueous media, meldrum’s acid, 4-hydroxycoumarin