Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

D.      Sellanes; L.      Scarone; G.      Mahler; E.      Manta; A.      Baz; S.      Dematteis; J.      Saldana; L.      Dominguez; P.      Wipf; G.      Serra

Letters in Drug Design & Discovery

Author(s): D. Sellanes, L. Scarone, G. Mahler, E. Manta, A. Baz, S. Dematteis, J. Saldana, L. Dominguez, P. Wipf and G. Serra

DOI: 10.2174/157018006775240962

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Synthesis and Evaluation of Anthelmintic and Cytotoxic Properties of Bis- 1,3-Azole Analogs of Natural Products

Page: [35 - 43] Pages: 9

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Abstract

Tandem cyclizations to [2,5] bis-1,3-azoles provided simplified and stable models of biological active marine natural products. The cytotoxic activity in HCT-15 cells and the effect on the L4 larvae of Nippostrongylus brasiliensis of the heterocycles were evaluated and provided data that serve for the preparation of bioselective new therapeutic agents.

Keywords: Bis-1,3-azoles, anthelmintic, cytotoxic, Bengazoles

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