Current Gene Therapy

Author(s): Vijapurapu Sai Vaishnavi*, Bala Murali Mohan Sanku, Sunil Kumar Kadiri, Mudigubba Manoj Kumar and Mahadevamma Lingaiah

DOI: 10.2174/0115665232262213240329034826

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Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach

Page: [22 - 33] Pages: 12

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Abstract

L-arginine is a semi-essential amino acid that plays a critical role in various physiological processes, such as protein synthesis, wound healing, immune function, and cardiovascular regulation. The use of L-arginine in pregnancy has been an emerging topic in the field of pharmacogenomics. L-arginine, an amino acid, plays a crucial role in the production of nitric oxide, which is necessary for proper placental development and fetal growth. Studies have shown that L-arginine supplementation during pregnancy can have positive effects on fetal growth, maternal blood pressure, and the prevention of preeclampsia. This emerging pharmacogenomic approach involves using genetic information to personalize L-arginine dosages for pregnant women based on their specific genetic makeup. By doing so, it may be possible to optimize the benefits of L-arginine supplementation during pregnancy and improve pregnancy outcomes. This paper emphasizes the potential applications of L-arginine in pregnancy and the use of pharmacogenomic approaches to enhance its effectiveness. Nonetheless, the emerging pharmacogenomic approach to the application of L-arginine offers exciting prospects for the development of novel therapies for a wide range of diseases.

Keywords: L-arginine, pregnancy, pharmacogenomics, nitric oxide, oligohydramnios, preeclampsia.