Targeted Mevalonate Pathway and Autophagy in Antitumor
Immunotherapy

Zongrui      Xing; Xiangyan      Jiang; Yuxia      Wu; Zeyuan      Yu
Abstract

Tumors of the digestive system are currently one of the leading causes of cancer-related death worldwide. Despite considerable progress in tumor immunotherapy, the prognosis for most patients remains poor. In the tumor microenvironment (TME), tumor cells attain immune escape through immune editing and acquire immune tolerance. The mevalonate pathway and autophagy play important roles in cancer biology, antitumor immunity, and regulation of the TME. In addition, there is metabolic crosstalk between the two pathways. However, their role in promoting immune tolerance in digestive system tumors has not previously been summarized. Therefore, this review focuses on the cancer biology of the mevalonate pathway and autophagy, the regulation of the TME, metabolic crosstalk between the pathways, and the evaluation of their efficacy as targeted inhibitors in clinical tumor immunotherapy.
Keywords: Mevalonate pathway, autophagy, metabolic crosstalk, antitumor immunotherapy, tumor microenvironment, digestive system.
Graphical Abstract

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Cite As
Current Cancer Drug Targets

Targeted Mevalonate Pathway and Autophagy in Antitumor Immunotherapy

Abstract

Graphical Abstract
