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Current Gene Therapy

Author(s): Arun Kumar Singh, Deepika Yadav and Rishabha Malviya*

DOI: 10.2174/0115665232258528231018113410

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Splicing DNA Damage Adaptations for the Management of Cancer Cells

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Abstract

Maintaining a tumour cell's resistance to apoptosis (organized cell death) is essential for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage, but its ultimate goal is always the same: the removal of damaged cells that might otherwise develop into tumours. Many chemotherapy drugs rely on cancer cells being able to undergo apoptosis as a means of killing them. The mechanisms by which DNA-damaging agents trigger apoptosis, the interplay between pro- and apoptosis-inducing signals, and the potential for alteration of these pathways in cancer are the primary topics of this review.

Keywords: Apoptosis, extrinsic pathway, p38 signaling, cancer, DNA damage, genetic therapy.

Graphical Abstract

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