Based on the Network Pharmacology to Analyze the Effect of Chuanxiong in Improving Diabetic Nephropathy

Page: [709 - 717] Pages: 9

  • * (Excluding Mailing and Handling)

Abstract

Aim: To explore the mechanism of diabetic nephropathy (DN) treated with Chuanxiong.

Background: The development of network pharmacology promotes the process of medicinal transformation of traditional Chinese medicine. This study took Chuanxiong as an example to analyze the active components in the treatment of DN.

Objective: Molecular docking and other technologies have effectively helped the complex find the disease's active ingredients.

Methods: The data of Chuanxiong was collected from the TCPSP database, DN gene expression data were collected through the NCBI database, and DN-related genes were obtained through differential analysis. In addition, the regulatory network of Chuanxiong and the main active components of DN treatment was constructed using String and Cytoscape tools. At the same time, PPI network interaction analysis was performed on core genes and GO. KEGG analysis was performed to predict essential genes using the Auto Dock tool.

Results: Eight active components of Chuanxiong were screened out. NCOA1 and NCOA2 could interact with Angelica lactone A, Myricetin, Chrysophanol, Chuanxiong, naphthalize, and Chrysophanol. Meanwhile, Angelica Lactone A, Myricetin, Chrysophanol, Chuanxiong, naphthafunolide, and Chrysophanol can affect the regulation of estrogen signaling pathway, endocrine and other factors regulating calcium reabsorption and adipogenesis of adipocytes through the regulation of steroid hormone stimulation and regulation of cAMP-dependent protein kinase complex.

Conclusion: NCOA1 and NCOA2 can be used as pharmacodynamic targets of Chuanxiong for improving DN.

[1]
Zhou, Z.; Jiang, L.; Zhao, Q.; Wang, Y.; Zhou, J.; Chen, Q.; Lv, J. Roles of pattern recognition receptors in diabetic nephropathy. J. Zhejiang Univ. Sci. B, 2020, 21(3), 192-203.
[http://dx.doi.org/10.1631/jzus.B1900490] [PMID: 32133797]
[2]
Griffin, T.P.; O’Shea, P.M.; Smyth, A.; Islam, M.N.; Wall, D.; Ferguson, J.; O’Sullivan, E.; Finucane, F.M.; Dinneen, S.F.; Dunne, F.P.; Lappin, D.W.; Reddan, D.N.; Bell, M.; O’Brien, T.; Griffin, D.G.; Griffin, M.D. Burden of chronic kidney disease and rapid decline in renal function among adults attending a hospital-based diabetes center in Northern Europe. BMJ Open Diabetes Res. Care, 2021, 9(1), e002125.
[http://dx.doi.org/10.1136/bmjdrc-2021-002125]
[3]
Zhang, H.; Qi, S.; Song, Y.; Ling, C. Artemisinin attenuates early renal damage in diabetic nephropathy rats through suppressing TGF-β1 regulator and activating the Nrf2 signaling pathway. Life Sci., 2020, 256, 117966.
[http://dx.doi.org/10.1016/j.lfs.2020.117966] [PMID: 32535079]
[4]
Sharma, D.; Kumar Tekade, R.; Kalia, K. Kaempferol in ameliorating diabetes-induced fibrosis and renal damage: An in vitro and in vivo study in diabetic nephropathy mice model. Phytomedicine, 2020, 76, 153235.
[http://dx.doi.org/10.1016/j.phymed.2020.153235] [PMID: 32563017]
[5]
ALTamimi. J.Z.; AlFaris, N.A.; AL-Farga, A.M.; Alshammari, G.M.; BinMowyna, M.N.; Yahya, M.A. Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a. J. Nutr. Biochem., 2021, 87, 108515.
[http://dx.doi.org/10.1016/j.jnutbio.2020.108515] [PMID: 33017608]
[6]
Wang, F.; Li, R.; Zhao, L.; Ma, S.; Qin, G. Resveratrol ameliorates renal damage by inhibiting oxidative stress-mediated apoptosis of podocytes in diabetic nephropathy. Eur. J. Pharmacol., 2020, 885, 173387.
[http://dx.doi.org/10.1016/j.ejphar.2020.173387] [PMID: 32710953]
[7]
Zuo, C.; Xu, G. Efficacy and safety of mineralocorticoid receptor antagonists with ACEI/ARB treatment for diabetic nephropathy: A meta‐analysis. Int. J. Clin. Pract., 2019, 73(12), e13413.
[http://dx.doi.org/10.1111/ijcp.13413] [PMID: 31464019]
[8]
Umanath, K.; Lewis, J.B. Update on diabetic nephropathy: Core curriculum 2018. Am. J. Kidney Dis., 2018, 71(6), 884-895.
[http://dx.doi.org/10.1053/j.ajkd.2017.10.026] [PMID: 29398179]
[9]
Xiang, E.; Han, B.; Zhang, Q.; Rao, W.; Wang, Z.; Chang, C.; Zhang, Y.; Tu, C.; Li, C.; Wu, D. Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Res. Ther., 2020, 11(1), 336.
[http://dx.doi.org/10.1186/s13287-020-01852-y] [PMID: 32746936]
[10]
Yuan, X.; Han, B.; Feng, Z.M.; Jiang, J.S.; Yang, Y.N.; Zhang, P.C. Chemical constituents of Ligusticum chuanxiong and their anti-inflammation and hepatoprotective activities. Bioorg. Chem., 2020, 101, 104016.
[http://dx.doi.org/10.1016/j.bioorg.2020.104016] [PMID: 32599365]
[11]
Zhang, Q.; Xu, S.; Qian, J. Pharmacological inhibition of MyD88 suppresses inflammation in tubular epithelial cells and prevents diabetic nephropathy in experimental mice. Acta Pharmacol. Sin., 2021, 43(2), 354-366.
[PMID: 34552217]
[12]
Song, Y; Nephrology, D Randomized controlled study of chuanxiong injection combined with benazepril in the treatment of diabetic nephropathy J. Pract. Tradit. Chin. Int. Med., 2019.
[13]
Chen, X.; Li, H.; Tian, L. Analysis of the physicochemical properties of acaricides based on lipinski’s rule of five. J. Comput. Biol., 2020, 27(9), 1397-1406.
[14]
Williams, R.; Karuranga, S.; Malanda, B. Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res. Clin. Prac., 2020, 162, 108072.
[15]
Deng, Y.; Li, N.; Wu, Y.; Wang, M.; Yang, S.; Zheng, Y.; Deng, X.; Xiang, D.; Zhu, Y.; Xu, P.; Zhai, Z.; Zhang, D.; Dai, Z.; Gao, J. Global, regional, and national burden of diabetes-related chronic kidney disease from 1990 to 2019. Front. Endocrinol. (Lausanne), 2021, 12, 672350.
[http://dx.doi.org/10.3389/fendo.2021.672350] [PMID: 34276558]
[16]
Cheng, H.T.; Xu, X.; Lim, P.S.; Hung, K.Y. Worldwide epidemiology of diabetes-related end-stage renal disease, 2000-2015. Diabetes Care, 2021, 44(1), 89-97.
[http://dx.doi.org/10.2337/dc20-1913] [PMID: 33203706]
[17]
Exploration of the compatibility of ligusticum wallichii in the prevention and treatment of diabetic nephropathy. China J. Chin. Med., 2012.
[18]
Walters, W.P. Going further than Lipinski’s rule in drug design. Expert Opin. Drug Discov., 2012, 7(2), 99-107.
[http://dx.doi.org/10.1517/17460441.2012.648612] [PMID: 22468912]
[19]
Legouis, D.; Ricksten, S.E.; Faivre, A.; Verissimo, T.; Gariani, K.; Verney, C.; Galichon, P.; Berchtold, L.; Feraille, E.; Fernandez, M.; Placier, S.; Koppitch, K.; Hertig, A.; Martin, P.Y.; Naesens, M.; Pugin, J.; McMahon, A.P.; Cippà, P.E.; de Seigneux, S. Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality. Nat. Metab., 2020, 2(8), 732-743.
[http://dx.doi.org/10.1038/s42255-020-0238-1] [PMID: 32694833]
[20]
Lichtenecker, D.C.K.; Argeri, R.; Castro, C.H.M.; Dias-da-Silva, M.R.; Gomes, G.N. Cross‐sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure. Clin. Exp. Pharmacol. Physiol., 2021, 48(7), 978-986.
[http://dx.doi.org/10.1111/1440-1681.13495] [PMID: 33711175]
[21]
Ingelfinger, J.R.; Rosen, C.J. Finerenone-halting relative hyperaldosteronism in chronic kidney disease. N. Engl. J. Med., 2020, 383(23), 2285-2286.
[http://dx.doi.org/10.1056/NEJMe2031382] [PMID: 33095527]
[22]
Liu, B.; Tu, Y.; Ni, G. Abelmoschus manihottotal flavones of ameliorates podocyte pyroptosis and injury in high glucose conditions by targeting METTL3-Dependent mA modification-mediated nlrp3-inflammasome activation and PTEN/PI3K/Akt signaling. Front. Pharmacol., 2021, 12, 667644.
[http://dx.doi.org/10.3389/fphar.2021.667644] [PMID: 34335245]
[23]
Zhang, H.; Liu, B.; Shi, X.; Sun, X. Long noncoding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases. Pharmacol. Ther., 2021, 221, 107744.
[http://dx.doi.org/10.1016/j.pharmthera.2020.107744] [PMID: 33181193]
[24]
Cheung, V.C.; Peng, C.Y. Marinić M; Sakabe, NJ; Aneas, I; Lynch, VJ; Ober, C; Nobrega, MA; Kessler, JA Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua. Cell Rep., 2021, 35(7), 109138.
[25]
Jheng, H.F.; Hayashi, K.; Matsumura, Y.; Kawada, T.; Seno, S.; Matsuda, H.; Inoue, K.; Nomura, W.; Takahashi, H.; Goto, T. Anti‐Inflammatory and antioxidative properties of isoflavones provide renal protective effects distinct from those of dietary soy proteins against diabetic nephropathy. Mol. Nutr. Food Res., 2020, 64(10), 2000015.
[http://dx.doi.org/10.1002/mnfr.202000015] [PMID: 32281228]
[26]
Kas, A; Bs, A; Kd, C 4-thiazolidinone-based derivatives rosiglitazone and pioglitazone affect the expression of antioxidant enzymes in different human cell lines. Biomed Pharmacother., 2021, 139, 111684.
[27]
Saw, G.; Krishna, K.; Gupta, N.; Soong, T.W.; Mallilankaraman, K.; Sajikumar, S.; Dheen, S.T. Epigenetic regulation of microglial phosphatidylinositol 3‐kinase pathway involved in long‐term potentiation and synaptic plasticity in rats. Glia, 2020, 68(3), 656-669.
[http://dx.doi.org/10.1002/glia.23748] [PMID: 31702864]
[28]
Gu, Y.; Chen, X.; Fu, S.; Liu, W.; Wang, Q.; Liu, K.J.; Shen, J. Astragali Radix isoflavones synergistically alleviate cerebral ischemia and reperfusion injury via activating estrogen receptor-PI3K-Akt signaling pathway. Front. Pharmacol., 2021, 12, 533028.
[http://dx.doi.org/10.3389/fphar.2021.533028] [PMID: 33692686]
Request history8.2.27PHP Version283msRequest Duration27MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[16:17:30] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[16:17:31] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[16:17:31] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[16:17:31] LOG.warning: Function strftime() is deprecated in /home/betabenthamscien/public_html/stor...
  • warninglog[16:17:31] LOG.warning: Function strftime() is deprecated in /home/betabenthamscien/public_html/stor...
  • Booting (125ms)time
  • Application (158ms)time
  • 1 x Application (55.79%)
    158ms
    1 x Booting (44.2%)
    125ms
    8 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    35 statements were executed, 2 of which were duplicates, 33 unique. Show only duplicated70.46ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('221948556','',1,1737994650,1737994650) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1737994650
      960μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('221948556','/article/128721',1,1737994650,1737994650)
      200μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 221948556 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 221948556) limit 1
      4.28msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 221948556
      • 1: 221948556
      • 2: 221948556
      • 3: 221948556
      • 4: 221948556
      • 5: 221948556
      • 6: 221948556
      • 7: 221948556
      • 8: 221948556
      • 9: 221948556
      • 10: 221948556
      • 11: 221948556
      • 12: 221948556
      • 13: 221948556
      • 14: 221948556
      • 15: 221948556
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:63
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=128721
      640μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 57 limit 1
      720μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 57
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=57) and sj.journal_id!=57 group by `j`.`nid`) as `aggregate_table`
      1.08msalphaeurekaselec_live_10_06_2022Subject.php#198
      Backtrace
      • 16. app/Models/Subject.php:198
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=57) and sj.journal_id!=57 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      860μsalphaeurekaselec_live_10_06_2022Subject.php#198
      Backtrace
      • 14. app/Models/Subject.php:198
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=57) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.19msalphaeurekaselec_live_10_06_2022Subject.php#218
      Backtrace
      • 16. app/Models/Subject.php:218
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=57) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.09msalphaeurekaselec_live_10_06_2022Subject.php#218
      Backtrace
      • 14. app/Models/Subject.php:218
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '128721'
      180μsalphaeurekaselec_live_10_06_2022Keywords.php#85
      Bindings
      • 0: 128721
      Backtrace
      • 13. app/Models/Keywords.php:85
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '128721'
      2.5msalphaeurekaselec_live_10_06_2022Article.php#1569
      Bindings
      • 0: 128721
      Backtrace
      • 13. app/Models/Article.php:1569
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs , `au`.*, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '128721' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      2.52msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 128721
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      250μsalphaeurekaselec_live_10_06_2022BundleOffer.php#113
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:113
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      400μsalphaeurekaselec_live_10_06_2022Article.php#1959
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1959
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 57 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      20.3msalphaeurekaselec_live_10_06_2022Issue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 57 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      14.21msalphaeurekaselec_live_10_06_2022Article.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 57 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      9.52msalphaeurekaselec_live_10_06_2022Article.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 128721 limit 1
      170μsalphaeurekaselec_live_10_06_2022Article.php#743
      Bindings
      • 0: 128721
      Backtrace
      • 14. app/Models/Article.php:743
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 128721 and content_type = 'article' order by status desc limit 1
      210μsalphaeurekaselec_live_10_06_2022Article.php#750
      Backtrace
      • 11. app/Models/Article.php:750
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 212538 limit 1
      790μsalphaeurekaselec_live_10_06_2022Meta.php#59
      Bindings
      • 0: 212538
      Backtrace
      • 14. app/Models/Meta.php:59
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#113
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:113
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'LDDD' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      220μsalphaeurekaselec_live_10_06_2022Article.php#2024
      Bindings
      • 0: LDDD
      Backtrace
      • 13. app/Models/Article.php:2024
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '128721' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      300μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '12857' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      250μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3468' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      230μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3468) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3468) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3468)
      640μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12857) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12857) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 12857)
      550μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 128721) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 128721) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 221948556 and j.to_ip >=221948556 )) and ((j.from_date <= 1737994651 and j.to_date >= 1737994651 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 128721)
      530μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '709' and is_uploaded = 1 and issue_id = 12857 order by cast(first_page as SIGNED) desc limit 1
      530μsalphaeurekaselec_live_10_06_2022Article.php#1818
      Bindings
      • 0: 709
      Backtrace
      • 14. app/Models/Article.php:1818
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '717' and is_uploaded = 1 and issue_id = 12857 order by cast(first_page as SIGNED) asc limit 1
      480μsalphaeurekaselec_live_10_06_2022Article.php#1830
      Bindings
      • 0: 717
      Backtrace
      • 14. app/Models/Article.php:1830
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      250μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      240μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 128721 limit 1
      2.4msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 128721
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 57 and `b`.`banner_from_date` <= 1737994651 and `b`.`banner_to_date` >= 1737994651 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.18msalphaeurekaselec_live_10_06_2022Banner.php#189
      Bindings
      • 0: 1
      • 1: J
      • 2: 57
      • 3: 1737994651
      • 4: 1737994651
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='95874a5e1a165d4556cdd768a874a8f4'
      380μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        xUoBAm01JdUrFJ41SxZ59yKHh3SEqEOUGOp7nPCr
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/article/128721" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        uc_cart_id
        95874a5e1a165d4556cdd768a874a8f4
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/128721
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "beta.benthamscience.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "XSRF-TOKEN=eyJpdiI6IlVKK3Ryc2xhRHdBaWdCa0ZBWWJJK1E9PSIsInZhbHVlIjoiSDhYK043azNUQXVLc3N2ZU0yekhxTnlJUUI0VVF0U3ZIaFJZUzF2bm5pcU42V3kweU5nbUhNcGJxbHM3Y0tFbHgySW90Wll3a1hOSWJOOFFsWkVrUUNZcnNBOHU1d1JzSDVDdHBCV0tyeVRqU2I1TDhteCthaFcwRC9Hb2xFVzciLCJtYWMiOiJiZTk1MDliZjQwMTNjYWQ2ZmM0YzhjYzMzM2YzNGM1NmUxNWNhZWQ3NDE2NDFhZjk2NTY4NzdiZjcyNjRjOWQzIiwidGFnIjoiIn0%3D; eurekaselectnew_session=eyJpdiI6IlNaQ0xYL3JNai9oSlJqYUdrdHhZbEE9PSIsInZhbHVlIjoiYXJwc3NoNFp6RmVHcm5MK3FDVWFIOU5pTDA2Y2ZFM3R5d2REWHBlaHIvMFREWWZselc2WFR0N09lQW5URUROS3NCK0lpWktqVGtaY0t3LzBYdmROcUw5b1ptYzAvMENLNDZibUNZUFFNaDhsQU52ekhIQk8rdEorMjdWVlZSMXYiLCJtYWMiOiJiMTUwMGViYzU2NTg0ODFiYjY3ZjA0NmI0NDFhMzQ1NTYzYWUxOTUyYWM2ZDBiNGZkZDI3MzllZTQxOWE2ZGQ4IiwidGFnIjoiIn0%3DXSRF-TOKEN=eyJpdiI6IlVKK3Ryc2xhRHdBaWdCa0ZBWWJJK1E9PSIsInZhbHVlIjoiSDhYK043azNUQXVLc3N2ZU0yekhxTnlJUUI0VVF0U3ZIaFJZUzF2bm5pcU42V3kweU5nbUhNcGJxbHM3Y0tFbHgySW90W" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:2 [ "XSRF-TOKEN" => "xUoBAm01JdUrFJ41SxZ59yKHh3SEqEOUGOp7nPCr" "eurekaselectnew_session" => "pT63psoumeLfpzcIPt2wm3PWefDdWtuaADgtrBTz" ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Mon, 27 Jan 2025 16:17:31 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkpnZmY0RStCbkM0S0VqeFhPZ1AxaGc9PSIsInZhbHVlIjoiSGNCZS9OQ1ZmcWs5OFZQc2hmZFVsSlBJb0FnN2drYWdRVHJ2dEh1bFFNZVRHU0VMSW1PR256cFBvNHBDY2FQUTJvTk9xQ1huOUtvYkU1MzU2Y05pZWY1WE1qZXBUZWhpZzJteEtLUU15QWUyNDdTelV6bzEybUZhWEx0K0xBcTciLCJtYWMiOiIzZWExMGZjMzMwMDY0MzMzMjM4MDg0MGQyNjYwODQzNDVkNjc5ZTM5ZDc5NzYyZWExNmVmYWNhMGU4NDU3Y2MxIiwidGFnIjoiIn0%3D; expires=Thu, 30 Jan 2025 04:17:31 GMT; Max-Age=216000; path=/; secure; samesite=strictXSRF-TOKEN=eyJpdiI6IkpnZmY0RStCbkM0S0VqeFhPZ1AxaGc9PSIsInZhbHVlIjoiSGNCZS9OQ1ZmcWs5OFZQc2hmZFVsSlBJb0FnN2drYWdRVHJ2dEh1bFFNZVRHU0VMSW1PR256cFBvNHBDY2FQUTJvTk9xQ" 1 => "eurekaselectnew_session=eyJpdiI6ImhiR042QWl2ZDNHM0VjN1h0SXk2a3c9PSIsInZhbHVlIjoiMVpaN0hTQWJITUs1ZzVaL3VtZjkyejhSVXdxSE9vR3FTSXREZE5RUHNvSWl6MHlqMGcxd05YZlFVZVptTWw5VmhOV0dXNjVhZnY2b2hBVy9oVmtjZ0ZPeEpMcmo1b2duSzlTbXJuK2NxZFh0bXh0QjlhVHBjc0w5M3NXVTc0NDUiLCJtYWMiOiJiZWYwNzgzZjJiZDZjODliYTQyNzc1YTAxYzAwNjllZTQ4MDY0Nzg3M2U2NjUzYjY2NjE1NWE2Zjc4YTczZGI4IiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=stricteurekaselectnew_session=eyJpdiI6ImhiR042QWl2ZDNHM0VjN1h0SXk2a3c9PSIsInZhbHVlIjoiMVpaN0hTQWJITUs1ZzVaL3VtZjkyejhSVXdxSE9vR3FTSXREZE5RUHNvSWl6MHlqMGcxd05YZlFVZVpt" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6IkpnZmY0RStCbkM0S0VqeFhPZ1AxaGc9PSIsInZhbHVlIjoiSGNCZS9OQ1ZmcWs5OFZQc2hmZFVsSlBJb0FnN2drYWdRVHJ2dEh1bFFNZVRHU0VMSW1PR256cFBvNHBDY2FQUTJvTk9xQ1huOUtvYkU1MzU2Y05pZWY1WE1qZXBUZWhpZzJteEtLUU15QWUyNDdTelV6bzEybUZhWEx0K0xBcTciLCJtYWMiOiIzZWExMGZjMzMwMDY0MzMzMjM4MDg0MGQyNjYwODQzNDVkNjc5ZTM5ZDc5NzYyZWExNmVmYWNhMGU4NDU3Y2MxIiwidGFnIjoiIn0%3D; expires=Thu, 30-Jan-2025 04:17:31 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6IkpnZmY0RStCbkM0S0VqeFhPZ1AxaGc9PSIsInZhbHVlIjoiSGNCZS9OQ1ZmcWs5OFZQc2hmZFVsSlBJb0FnN2drYWdRVHJ2dEh1bFFNZVRHU0VMSW1PR256cFBvNHBDY2FQUTJvTk9xQ" 1 => "eurekaselectnew_session=eyJpdiI6ImhiR042QWl2ZDNHM0VjN1h0SXk2a3c9PSIsInZhbHVlIjoiMVpaN0hTQWJITUs1ZzVaL3VtZjkyejhSVXdxSE9vR3FTSXREZE5RUHNvSWl6MHlqMGcxd05YZlFVZVptTWw5VmhOV0dXNjVhZnY2b2hBVy9oVmtjZ0ZPeEpMcmo1b2duSzlTbXJuK2NxZFh0bXh0QjlhVHBjc0w5M3NXVTc0NDUiLCJtYWMiOiJiZWYwNzgzZjJiZDZjODliYTQyNzc1YTAxYzAwNjllZTQ4MDY0Nzg3M2U2NjUzYjY2NjE1NWE2Zjc4YTczZGI4IiwidGFnIjoiIn0%3D; path=/; secure; httponlyeurekaselectnew_session=eyJpdiI6ImhiR042QWl2ZDNHM0VjN1h0SXk2a3c9PSIsInZhbHVlIjoiMVpaN0hTQWJITUs1ZzVaL3VtZjkyejhSVXdxSE9vR3FTSXREZE5RUHNvSWl6MHlqMGcxd05YZlFVZVpt" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "xUoBAm01JdUrFJ41SxZ59yKHh3SEqEOUGOp7nPCr" "_previous" => array:1 [ "url" => "https://beta.benthamscience.com/article/128721" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "uc_cart_id" => "95874a5e1a165d4556cdd768a874a8f4" "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-01-27 16:17:31GET/article/12872158351