Chimeric Antigen Receptor (CAR) T-cell Therapy: A New Genetically Engineered
Method of Immunotherapy for Cancer

Arun   Kumar   Singh; Rishabha      Malviya; Amrita      Singh; Sonali      Sundram; Sudhanshu      Mishra
Abstract

Chimeric antigen receptor (CAR T) cell treatment for solid tumours faces significant challenges. CAR T cells are unable to pass the vascular barrier in tumours due to a lack of endothelial leukocyte adhesion molecules. The invasion, activity, and durability of CAR T cells may be hampered by additional immunosuppressive mechanisms present in the solid tumour environment. The use of CAR T cells to attack cancer vascular endothelial metabolic targets from within the blood may simplify the fight against cancer. These are the principles that govern our examination of CAR T cell treatment for tumor cells, with a specific eye toward tumour venous delivery. CAR T cells may also be designed such that they can be readily, safely, and successfully transferred.
Keywords: Solid tumor, angiogenesis, targeted therapy, CAR T cells, blood diffusion, tumour.
Graphical Abstract

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Cite As
Current Cancer Drug Targets

Chimeric Antigen Receptor (CAR) T-cell Therapy: A New Genetically Engineered Method of Immunotherapy for Cancer

Abstract

Graphical Abstract
