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Letters in Drug Design & Discovery

Author(s): Yan Li*, Lei Zhang* and Rongjian Dong

DOI: 10.2174/1570180819666220819150351

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Research Progress in Regulation of Ferroptosis by Epigallocatechin-3- gallate in Tumor Cells

Page: [1877 - 1883] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

Ferroptosis is an identified form of regulated cell death different from cell necrosis, autophagy, and apoptosis, characterized by iron-dependent accumulation of lipid reactive oxygen species. The processes of ferroptosis are mainly related to iron metabolism disorder, inactivation of glutathione peroxidase 4 (GPX4), and coenzyme Q10-dependent pathway. Inducing ferroptosis is considered a promising strategy to fight against cancers, especially apoptosis-resistant tumors. Epigallocatechin-gallate (EGCG) is the predominately active substance in green tea, which is widely consumed worldwide as a beverage. Recently, EGCG has been proved to play an important role in inducing ferroptosis by modulation of the iron metabolism and promotion of glutathione peroxidase 4 (GPX4) protein degradation. Therefore, this review mainly elaborates the regulating effects of EGCG on ferroptosis, aiming to create a new space for the research and development of novel anticancer drugs.

Keywords: Ferroptosis, epigallocatechin-3-gallate, cancer treatment, iron metabolism, HSPA5, green tea

Graphical Abstract

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