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Letters in Drug Design & Discovery

Author(s): Yan Tan, Jiajia Lang, Meilun Tang, Pengbing Mi* and Xing Zheng*

DOI: 10.2174/1570180819666220806145656

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Synthesis and Pharmacological Activity of 4', 4''- bit Modified Curcumin Derivatives

Page: [1884 - 1897] Pages: 14

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Abstract

Background: Curcumin is a polyphenol compound extracted from plant turmeric with high pharmacological activities. The clinical application of curcumin is limited due to the shortcomings of poor water solubility, instability, and low bioavailability.

Objective: Modifying the 4', 4''-bit of curcumin is an effective strategy to improve the pharmacological activity of curcumin.

Conclusion: In this review, we focused on the strategy of synthesis, medicinal properties, and structurefunction relationship of 4', 4''-bit modified curcumin derivatives.

Keywords: Curcumin, 4', 4''-bit modified, pharmacological activity, synthesis, derivative, structure-function.

Graphical Abstract

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