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Current Cancer Drug Targets

Author(s): Li-Xia Xiao, Hui-Nian Zhou and Zuo-Yi Jiao*

DOI: 10.2174/1568009622666220806121008

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Present and Future Prospects of the Anti-cancer Activities of Saikosaponins

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Abstract

Since their discovery, saikosaponins (SSs) have been found to play an important role in treating a variety of cancers via diverse mechanisms of action. This review summarizes the current research status and prospects of the anti-cancer activities of SSs, providing novel insights into the limitations of current studies. In addition, it discusses whether SSs can be applied in immunotherapy and the possible mechanisms by which SSs may facilitate immunotherapy. The research is significant to understanding the anti-cancer potents of SSs in the development of SSs-based therapeutic strategies and clinical practice.

Keywords: Saikosaponin A, saikosaponin B, saikosaponin C, saikosaponin D, cancer, MDR.

Graphical Abstract

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