Abstract

Diversity-Oriented Synthesis (DOS) aims to broaden the frontier of accessible collections of complex and diverse small molecules. This review endeavours to dissect the DOS concept through three elements of diversity: building block, stereochemistry, and skeleton. Recent examples in the literature that emphasize the efficient combinations of these elements to generate diversity are reported.

Keywords: Diversity-Oriented Synthesis, small molecules, complexity, diversity, multicomponent reactions, stereodivergent reactions, skeletal divergent reactions, chemical space