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Letters in Drug Design & Discovery

Author(s): Amaresh Mishra, Faizan Abul Qais, Yamini Pathak, Ihosvany Camps and Vishwas Tripathi*

DOI: 10.2174/1570180819666220401142351

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Triamcinolone as a Potential Inhibitor of SARS-CoV-2 Main Protease and Cytokine Storm: An In silico Study

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Abstract

Background: An ongoing global public health concern is the emerging COVID-19 pandemic triggered by acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mpro, a main protease of SARSCoV- 2, has been established as a potential drug target because of its direct role in viral replication and ability to infiltrate the multiple host pathways.

Objective: This research aims to classify new therapeutic drug candidates who may be repositioned for COVID-19 therapeutics.

Methods: We have taken similar drug compounds of Dexamethasone and targeted the main protease of SARS-CoV-2 (Mpro) along with the key molecules involved in the 'cytokine storm.' Further, we did MD simulations and calculated the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) on the active site of the main protease of SARS-CoV-2 (Mpro) and TNF-α, IL-6, & IL-1β to explore the binding affinity and stability.

Results: Based on our study outcome, Triamcinolone emerged as the most promising inhibitor of the main protease of SARS-CoV-2 (Mpro) and the cytokine storm molecules, i.e., TNF-α, IL-6, and IL-1β.

Conclusion: This research investigates the repositioning of COVID-19 drugs as a new therapeutic application.

Keywords: COVID-19, cytokine storm, main protease, molecular docking, MD simulation, protease inhibitor, triamcinolone.

Graphical Abstract

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