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Combinatorial Chemistry & High Throughput Screening

Author(s): Muhammad Pervaiz*, Ikram Ahmad, Zohaib Saeed, Muhammad Sagir, Umer Younas, Muhammad Bilal Tahir*, Awais Ahmad, Ayoub Rashid, Quratulain Syed and Ahmad Adnan

DOI: 10.2174/1386207325666210927092623

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Amalgamation and Scrutinizing of Leucine Derivatives Schiff Bases Complexes as Antimicrobial Agent

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Abstract

The enhanced applications of Schiff bases metal complexes of amino acid derivatives have captured the attention of researchers for the synthesis of leucine derivatives of Schiff bases metal complexes. Amino acids are considered to be essential part of food supplements as well as derivatives of Schiff bases in coordination chemistry due to their donor ability. The leucine derivatives Schiff bases ligand have been synthesized by condensation reaction between amine of leucine with aldehyde or ketone bearing molecules attached with them. These complexes were characterized by different spectroscopic tools in order to confirm their structural geometries. The structural geometries are considered to be very important in order to improve the antimicrobial potential of leucine derivative metal complexes. By taking into account the antimicrobial potential of titled compounds, a comprehensive review of leucine derivatives of Schiff bases metal complexes has been compiled.

Keywords: Leucine, metal complexes, schiff bases ligand, biological studies, amino acid derivative, antibacterial agent.

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