Abstract
As one of the most conservative proteins in evolution, Y-box-binding protein 1 (YB-1)
has long been considered as a potential cancer target. YB-1 is usually poorly expressed in normal
cells and exerts cellular physiological functions such as DNA repair, pre-mRNA splicing and mRNA
stabilizing. In cancer cells, the expression of YB-1 is up-regulated and undergoes nuclear translocation
and contributes to tumorigenesis, angiogenesis, tumor proliferation, invasion, migration
and chemotherapy drug resistance. During the past decades, a variety of pharmacological tools
such as siRNA, shRNA, microRNA, circular RNA, lncRNA and various compounds have been developed
to target YB-1 for cancer therapy. In this review, we describe the physiological characteristics
of YB-1 in detail, highlight the role of YB-1 in tumors and summarize the current therapeutic
methods for targeting YB-1 in cancer.
Keywords:
Y-box-binding protein 1, cancer, nuclear translocation model, siRNA, shRNA, microRNA, circular RNA, lncRNA.
Graphical Abstract
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