Abstract

The primary literature concerning the combinatorial synthesis of organophosphorus compounds is reviewed and discussed. The subject matter is divided into three main sections describing the solid phase, solution phase and solvent- free synthesis of phosphorus containing organic molecules. The review covers the synthesis of compounds in which the final products contain phosphorus-carbon bonds, primarily phosphonates, phosphinates, phosphine oxides and phosphines.

Keywords: carbonylaminophosphonates, tyrosine phosphatase, Phosphononucleotides, solid phase synthesis, Sulfide, Polymer Supported base