Abstract
The recent pandemic caused by a novel coronavirus known as SARS-CoV-2 has caught
the international community by surprise. There is still no effective vaccine or treatment option
against this virus. In this perspective, we discussed the potential protective and therapeutic effects
of chitosan, as an FDA-approved biomolecule, against COVID-19 and influenza viruses.
Keywords:
Chitosan, COVID-19, immune response, innate Immunity, biotherapeutic, macromolecule.
[7]
Shi, Y.; Wang, Y.; Shao, C.; Huang, J.; Gan, J.; Huang, X. COVID-19 infection: the perspectives on immune responses; Nature Publishing Group, 2020.
[10]
Knorr, D. Use of chitinous polymers in food: a challenge for food research and development; Food Technology: USA, 1984.
[15]
Muzzarelli, R.; Mattioli-Belmonte, M.; Muzzarelli, B. Advances in Chitin. SciLyon. Andru., 1998, 2, 219-224.
[20]
Sun, Q.S.; Zhang, J.L.; Han, D.Q.; Yang, Y.B.; Zhu, L.; Yu, L. Characterization and immunological evaluation of chitosan nanoparticles as adjuvants for bovine coronavirus N protein; Publ, T., Ed.; Applied Mechanics and Materials, 2012, pp. 113-120.
[26]
Pyrc, K.; Milewska, A.; Nowakowska, M.; Szczubialka, K.; Kaminski, K. The use of chitosan polymer in the treatment and prevention of infections caused by coronaviruses; Google Patents, 2015.
[27]
Alitongbieke, G.; Li, X-M.; Wu, Q-C.; Lin, Z-C.; Huang, J-F.; Xue, Y. Study on β-Chitosan against the binding of SARS-CoV-2S-RBD/ACE2. bioRxiv, 2020.
[42]
Keefe, D. Agency Response Letter GRAS Notice No. GRN000424. FDA ucm335743, 2012.