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Combinatorial Chemistry & High Throughput Screening

Author(s): A. G.M. Barrett, S. M. Cramp, R. S. Roberts and F. J. Zecri

DOI: 10.2174/1386207003331733

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Chromatography-Free Synthesis of 1,2,4-Oxadiazoles Using ROMPGEL-Supported Acylating Reagents

Page: [131 - 138] Pages: 8

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Abstract

1,2,4-Oxadiazoles were synthesized in solution from aromatic amidoximes and acylating agents supported on a ring opening metathesis polymer (ROMPGEL) backbone. High yields and purities of the 1,2,4-oxadiazoles were obtained with minimal purification.

Keywords: Chromatography free synthesis, Acylating reagents, 1,2,4 oxadiazoles, Ring opening metathesis polymer, Polymers ROMPGELs