Abstract

Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.

Keywords: Resin-Bound Organic Compounds, UV-Vis spectra, Gel-phase 19F NMR, Dansylhydrazine, Fourier Transform infrared, Hydroxybenzotriazole hydrate, Nuclear magnetic resonance, Tetrahydrofuran, Diisopropylethylamine, hexafluorophosphate