Abstract

Dynamic combinatorial chemistry is based on the reversible combination of initial building blocks to form dynamic combinatorial libraries. It has recently emerged as an efficient strategy to detect and to evaluate affinity between the library products and a target molecule. In this review, examples from various fields of chemistry and biochemistry are presented and extensively discussed. The last section deals with the practical aspects for implementing this approach.

Keywords: Dynamic Combinatorial, potential diversity, dynamic generation, Si NMR, polycyclic oligomers, rational equilibiria, intramollecular forces, oligoamide 2