Search Result "hit-to-lead optimization"
Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 6 Issue: 1 Year: 2003 Page: 51-66
Author(s): Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W. Thomas
Novel, Acidic CCR2 Receptor Antagonists: From Hit to Lead
Journal: Letters in Drug Design & Discovery
Volume: 4 Issue: 3 Year: 2007 Page: 185-191
Author(s): D. Zou, H.-X. Zhai, J. Eckman, P. Higgins, M. Gillard, L. Knerr, S. Carre, P. Pasau, P. Collart, J. Grassi
A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 123-130
Author(s): X. Yang, D. Parker, L. Whitehead, N. S. Ryder, B. Weidmann, M. Stabile-Harris, D. Kizer, M. McKinnon, A. Smellie, D. Powers
Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases
Journal: Current Drug Discovery Technologies
Volume: 1 Issue: 3 Year: 2004 Page: 201-210
Author(s): Sergey E. Tkachenko, Ilya Okun, Konstantin V. Balakin, Charles E. Petersen, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko
The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization
Journal: Current Medicinal Chemistry
Volume: 26 Issue: 2 Year: 2019 Page: 3838-3873
Author(s): Agostino Bruno,Gabriele Costantino,Luca Sartori,Marco Radi
Computational Approaches for Fragment Optimization
Journal: Current Computer-Aided Drug Design
Volume: 3 Issue: 1 Year: 2007 Page: 69-83
Author(s): Eric Vangrevelinghe, Simon Rudisser
Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization
Journal: Letters in Drug Design & Discovery
Volume: 4 Issue: 4 Year: 2007 Page: 263-271
Author(s): O. A. Dasse, J. L. Evans, H.-X. Zhai, D. Zou, J. T. Kintigh, F. Chan, K. Hamilton, E. Hill, J. B. Eckman, P. J. Higgins, A. Volosov, P. Collart, J.-M. Nicolas, R.K. Kondru, C.E. Schwartz
Improvement of “Hit-to-Lead” Optimization by Integration of in Vitro HTS Experimental Models for Early Determination of Pharmacokinetic Properties
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 6 Year: 2002 Page: 459-472
Author(s): Ilona Kariv, Robyn A. Rourick, Daniel B. Kassel, Thomas D.Y. Chung
Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization
Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 13 Issue: 10 Year: 2013 Page: 1614-1635
Author(s): Olivier Provot,Abdallah Hamze,Jean-François Peyrat,Jean-Daniel Brion,Mouad Alami
19F-NMR in Target-based Drug Discovery
Journal: Current Medicinal Chemistry
Volume: 26 Issue: 26 Year: 2019 Page: 4964-4983
Author(s): CongBao Kang