Search Result "hit rate"
Lead Generation - Enhancing the Success of Drug Discovery by Investing in the Hit to Lead Process
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 6 Issue: 1 Year: 2003 Page: 51-66
Author(s): Alexander Alanine, Matthias Nettekoven, Edward Roberts, Andrew W. Thomas
Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases
Journal: Current Drug Discovery Technologies
Volume: 1 Issue: 3 Year: 2004 Page: 201-210
Author(s): Sergey E. Tkachenko, Ilya Okun, Konstantin V. Balakin, Charles E. Petersen, Yan A. Ivanenkov, Nikolay P. Savchuk, Andrey A. Ivashchenko
Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays
Journal: Current Topics in Medicinal Chemistry
Volume: 10 Issue: 3 Year: 2010 Page: 368-382
Author(s): Stephanie Ludewig, Markus Kossner, Markus Schiller, Knut Baumann, Tanja Schirmeister
Proteolytic Cleavage of Notch: “HIT and RUN”
Journal: Current Molecular Medicine
Volume: 11 Issue: 4 Year: 2011 Page: 255-269
Author(s): G. van Tetering, M. Vooijs
NMR Screening and Hit Validation in Fragment Based Drug Discovery
Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 1 Year: 2011 Page: 43-67
Author(s): Ramon Campos-Olivas
A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the âH Scoreâ for Hit Nomination & Gene Prioritization
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 15 Issue: 9 Year: 2012 Page: 686-704
Author(s): Bhavneet Bhinder,Hakim Djaballah
A Collaborative Hit-to-Lead Investigation Leveraging Medicinal Chemistry Expertise with High Throughput Library Design, Synthesis and Purification Capabilities
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 9 Issue: 2 Year: 2006 Page: 123-130
Author(s): X. Yang, D. Parker, L. Whitehead, N. S. Ryder, B. Weidmann, M. Stabile-Harris, D. Kizer, M. McKinnon, A. Smellie, D. Powers
Rational Prediction with Molecular Dynamics for Hit Identification
Journal: Current Topics in Medicinal Chemistry
Volume: 12 Issue: 18 Year: 2012 Page: 2002-2012
Author(s): Sara E. Nichols,Robert V. Swift,Rommie E. Amaro
Integrity Profiling of High Throughput Screening Hits Using LC-MS and Related Techniques
Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 8 Issue: 6 Year: 2005 Page: 459-466
Author(s): Edward H. Kerns, Li Di, Jim Bourassa, Jonathan Gross, Nelson Huang, Hanlan Liu, Teresa Kleintop, Lisa Nogle, Larry Mallis, Chris Petucci, Susan Petusky, Mark Tischler, Chantel Sabus, Ani Sarkahian, Mairead Young, Mei-yi Zhang, Donna Huryn, Oliver McConnell, Guy Carter
Genomes to Hits In Silico - A Country Path Today, A Highway Tomorrow: A Case Study of Chikungunya
Journal: Current Pharmaceutical Design
Volume: 19 Issue: 26 Year: 2013 Page: 4687-4700
Author(s): Anjali Soni,Khushhali M. Pandey,Pratima Ray,B. Jayaram