Search Result "TDI IC50 shift"
An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes
Journal: Drug Metabolism Letters
Volume: 2 Issue: 1 Year: 2008 Page: 51-59
Author(s): Loren M. Berry, Zhiyang Zhao
Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach
Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 43-53
Author(s): Sophie Mukadam, Suzanne Tay, Daniel Tran, Leslie Wang, Erlie M. Delarosa, S. Cyrus Khojasteh, Jason S. Halladay, Jane R. Kenny
Higher Throughput Human Hepatocyte Assays for the Evaluation of Time-Dependent Inhibition of CYP3A4
Journal: Drug Metabolism Letters
Volume: 5 Issue: 3 Year: 2011 Page: 183-191
Author(s): Albert P. Li, Utkarsh Doshi
In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities
Journal: Drug Metabolism Letters
Volume: 9 Issue: 1 Year: 2015 Page: 48-62
Author(s): Charles Awortwe,Vamshi K. Manda,Cristina Avonto,Shabana I. Khan,Ikhlas A. Khan,Larry A. Walker,Patrick J. Bouic,Bernd Rosenkranz
Comprehensive Assessment of ADMET Risks in Drug Discovery
Journal: Current Pharmaceutical Design
Volume: 15 Issue: 1 Year: 2009 Page: 2195-2219
Author(s): Jianling Wang
Emerging In Vitro Tools to Evaluate Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions
Journal: Current Drug Discovery Technologies
Volume: 7 Issue: 3 Year: 2010 Page: 199-222
Author(s): Cormac Concannon, Desmond A. Hennelly, Simon Noott, Dipak K. Sarker, Chuang Lu, Mingxiang Liao, Lawrence Cohen, Cindy Q. Xia
In Vitro Cytochrome P450 Inhibition and Induction
Journal: Current Drug Metabolism
Volume: 9 Issue: 9 Year: 2008 Page: 928-939
Author(s): Robert L. Walsky, Sherri E. Boldt
Farnesylated Proteins as Anticancer Drug Targets: From Laboratory to the Clinic
Journal: Current Medicinal Chemistry - Anti-Cancer Agents
Volume: 4 Issue: 2 Year: 2004 Page: 123-138
Author(s): Patrizia Russo, Maura Loprevite, Alfredo Cesario, Andrea Ardizzoni
Chemical Constituents and Biological Activities of Vietnamese Medicinal Plants
Journal: Current Topics in Medicinal Chemistry
Volume: 3 Issue: 2 Year: 2003 Page: 227-248
Author(s): Arjun H. Banskota, Yasuhiro Tezuka, Quan Le Tran, Shigetoshi Kadota
Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia
Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 6 Year: 2011 Page: 696-725
Author(s): Paul J. Coleman, Christopher D. Cox, Anthony J. Roecker