Search Result "PDK1 kinase"


Targeting PDK1 in Cancer

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 1 Year: 2011 Page: 2763-2769
Author(s): C. Raimondi, M. Falasca

A New Molecular Target of Insulin Action: Regulating the Pivotal PDK1

Journal: Current Drug Targets - Immune, Endocrine & Metabolic Disorders
Volume: 1 Issue: 3 Year: 2001 Page: 209-221
Author(s): K.L.R. Wick, F. Liu

Research Article

Investigation of Binding Characteristics of Phosphoinositide-dependent Kinase-1 (PDK1) Co-crystallized Ligands Through Virtual Pharmacophore Modeling Leading to Novel Anti-PDK1 Hits

Journal: Medicinal Chemistry
Volume: 16 Issue: 7 Year: 2020 Page: 860-880
Author(s): Iman A. Mansi,Mahmoud A. Al-Sha'er,Nizar M. Mhaidat,Mutasem O. Taha,Rand Shahin

Research Article

Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 20 Issue: 4 Year: 2020 Page: 476-485
Author(s): Iman Mansi,Mahmoud A. Al-Sha'er,Nizar Mhaidat,Mutasem Taha

Efficient Identification of Novel Leads by Dynamic Focused Screening: PDK1 Case Study

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 13 Issue: 1 Year: 2010 Page: 16-26
Author(s): Dongyu Sun, Joon Jung, Thomas S. Rush III, Zangwei Xu, Michael J. Weber, Ekaterina Bobkova, Alan Northrup, Ilona Kariv

Review Article

3-Phosphoinositide-Dependent Kinase 1 as a Therapeutic Target for Treating Diabetes

Journal: Current Diabetes Reviews
Volume: 21 Issue: 4 Year: 2025 Page: 47-56
Author(s):

Research Article

PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 20 Issue: 7 Year: 2020 Page: 828-833
Author(s): Xiaohua Zhang,Shan Zhong

Src Family Kinases: Potential Targets for the Treatment of Human Cancer and Leukemia

Journal: Current Pharmaceutical Design
Volume: 9 Issue: 2 Year: 2003 Page: 2043-2059
Author(s): Markus Warmuth, Robert Damoiseaux, Yi Liu, Doriano Fabbro, Nathanael Gray

Kinases as Targets for ENaC Regulation

Journal: Current Molecular Pharmacology
Volume: 6 Issue: 1 Year: 2013 Page: 50-64
Author(s): Deborah Baines

A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents

Journal: Letters in Drug Design & Discovery
Volume: 5 Issue: 6 Year: 2008 Page: 369-376
Author(s): Leyte L. Winfield, Dayle M. Smith, Kalani Halemano, Carmine S. Leggett

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