Recent Patents on CNS Drug Discovery (Discontinued)

Aims & Scope

Recent Patents on CNS Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of CNS drug discovery e.g. novel bioactive compounds, analogs & targets. A ...read more

  • ISSN (Print): 1574-8898
  • ISSN (Online): 2212-3954
  • Volume: 10
  • Issues: 2, 2015
Recent Patents on CNS Drug Discovery (Discontinued)

Volume 10, Issue 2, 2015


Editorial
Meet Our Editorial Board Member

Pp: 73-74

Author(s): Gjumrakch Aliev

DOI: 10.2174/157488981002160919194411

Editorial
Editorial (Thematic Issue: From Old Cannabinoids to Emerging New Synthetic Derivatives with Potential Therapeutic Application in Neurological Disorders)

Pp: 75-75

Author(s): Anna M. Malfitano

DOI: 10.2174/157488981002160919201100

Research Article
Peptide Agonists and Antagonists with Potential Application in Neurological Disorders

Pp: 76-89

Author(s): Anna Russo, Sara La Manna, Giancarlo Morelli, Ettore Novellino and Daniela Marasco

DOI: 10.2174/1574889810666160425121833

Research Article
Endocannabinoid System in Neurological Disorders

Pp: 90-112

Author(s): Roberta Ranieri, Chiara Laezza, Maurizio Bifulco, Daniela Marasco and Anna M. Malfitano

DOI: 10.2174/1574889810999160719105433

Research Article
Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis

Pp: 113-121

Author(s): Anna M. Malfitano, Chiara Laezza, Simona Pisanti, Clementina Manera and Maurizio Bifulco

DOI: 10.2174/1574889810666160421121726

Research Article
Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases

Pp: 122-141

Author(s): Andrea Chicca, Chiara Arena and Clementina Manera

DOI: 10.2174/1574889810999160603185126

Research Article
Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders

Pp: 142-156

Author(s): Clementina Manera, Chiara Arena and Andrea Chicca

DOI: 10.2174/1574889810666160519113853

Research Article
Phytocannabinoids and Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders

Pp: 157-177

Author(s): Roberta Ranieri, Daniela Marasco, Maurizio Bifulco and Anna M. Malfitano

DOI: 10.2174/1574889810666160517123938

Research Article
Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response

Pp: 178-203

Author(s): Roberta Ranieri, Chiara Laezza, Maurizio Bifulco, Daniela Marasco and Anna M. Malfitano

DOI: 10.2174/1574889810666160620103725

Review Article
Neuropharmacological Properties of Withania somnifera - Indian Ginseng: An Overview on Experimental Evidence with Emphasis on Clinical Trials and Patents

Pp: 204-215

Author(s): Sarat C. Yenisetti, M. J. Manjunath and Muralidhara

DOI: 10.2174/1574889810666160615014106

Patent Selections

Pp: 216-217

DOI: 10.2174/157488981002160919210107

Acknowledgement
Acknowledgements to Reviewers

Pp: 218-218

DOI: 10.2174/157488981002160919210209

Acknowledgement
Farewell Note

Pp: 219-219

Author(s): Vincenzo Di Marzo

DOI: 10.2174/157488981002160919210856

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      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
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      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
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      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
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      • 10: 51269529
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      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:63
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
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      • 13. app/Models/Issue.php:157
      • 14. app/Http/Controllers/IssueController.php:861
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/IssueController.php:863
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 13. app/Models/Volume.php:88
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      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select v.*, j.title, j.subtitle, y.year from volume v inner join journal j on v.journal_id = j.journal_id inner join year y on v.year_id = y.id where 1 and v.volume_id = 1611
      340μsbetabenthamscien_newVolume.php#292
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      • 11. app/Models/Volume.php:292
      • 12. app/Http/Controllers/IssueController.php:867
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 62 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      9.01msbetabenthamscien_newArticle.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/IssueController.php:868
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 62 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      2.49msbetabenthamscien_newArticle.php#527
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      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/IssueController.php:869
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select substring_index(GROUP_CONCAT(i.nicename ORDER BY i.priority SEPARATOR ', '), ',', 3) as indexing_title, COUNT(i.nicename) as indexing_occurrences from `indexing_journal` as `ij` inner join `indexing_agencies` as `i` on `ij`.`index_id` = `i`.`index_id` where `ij`.`journal_id` = 62 and `i`.`status` = 1 and `i`.`index_flag` = 1 group by `ij`.`journal_id` limit 1
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      • 14. app/Models/Indexing.php:415
      • 15. app/Http/Controllers/IssueController.php:870
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `journal` where `journal_id` = 62 limit 1
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      • 14. app/Models/Article.php:426
      • 15. app/Http/Controllers/IssueController.php:872
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from (select a.publish_on,a.article_id,a.elocator, a.nid,a.pmid, a.title,a.altmetric_score,a.altmetric_url,a.kudos_url, j.content_type_access_id, first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"), a.graph_abs_lg_filename,a.is_epub, a.is_epub as epub, a.graph_abs_sm_filename,a.journal_id,a.volume_id,a.issue_id, a.doi,m.month,y.year, at.type_name article_type_name,a.html_filename,a.prc_filename,a.epub_filename,v.volume_name,i.title as issue, i.type as issue_type, js.js_title, js.js_id, (select GROUP_CONCAT(CONCAT(COALESCE(first_name, ""),"", last_name)) from author aa where aa.article_id = a.article_id) as authors from `article` as `a` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal_section` as `js` on `js`.`js_id` = `a`.`js_id` left join `journal_access` as `j` on `a`.`article_id` = `j`.`content_type_id` and `j`.`content_type` = 'a' left join `issue` as `i` on `a`.`issue_id` = `i`.`issue_id` left join `month` as `m` on `i`.`month_id` = `m`.`id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_uploaded = 1 and a.issue_id = 7258 group by `a`.`article_id`) as `aggregate_table`
      11msbetabenthamscien_newArticle.php#468
      Backtrace
      • 16. app/Models/Article.php:468
      • 17. app/Http/Controllers/IssueController.php:872
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.publish_on,a.article_id,a.elocator, a.nid,a.pmid, a.title,a.altmetric_score,a.altmetric_url,a.kudos_url, j.content_type_access_id, first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"), a.graph_abs_lg_filename,a.is_epub, a.is_epub as epub, a.graph_abs_sm_filename,a.journal_id,a.volume_id,a.issue_id, a.doi,m.month,y.year, at.type_name article_type_name,a.html_filename,a.prc_filename,a.epub_filename,v.volume_name,i.title as issue, i.type as issue_type, js.js_title, js.js_id, (select GROUP_CONCAT(CONCAT(COALESCE(first_name, ""),"", last_name)) from author aa where aa.article_id = a.article_id) as authors from `article` as `a` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal_section` as `js` on `js`.`js_id` = `a`.`js_id` left join `journal_access` as `j` on `a`.`article_id` = `j`.`content_type_id` and `j`.`content_type` = 'a' left join `issue` as `i` on `a`.`issue_id` = `i`.`issue_id` left join `month` as `m` on `i`.`month_id` = `m`.`id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_uploaded = 1 and a.issue_id = 7258 group by `a`.`article_id` order by cast(a.article_no as SIGNED) asc, a.publish_on asc limit 20 offset 0
      1.69msbetabenthamscien_newArticle.php#468
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      • 14. app/Models/Article.php:468
      • 15. app/Http/Controllers/IssueController.php:872
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '1611' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      360μsbetabenthamscien_newContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:900
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '7258' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      340μsbetabenthamscien_newContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:907
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1611) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1611) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 1611)
      780μsbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:919
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258)
      590μsbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:932
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `journal_access` where `content_type_id` in (78421, 78422, 75166, 77134, 75115, 76230, 75830, 75744, 76685, 76562, 78423, 78424, 78425) and `content_type` = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      740μsbetabenthamscien_newContentAccess.php#616
      Bindings
      • 0: 78421
      • 1: 78422
      • 2: 75166
      • 3: 77134
      • 4: 75115
      • 5: 76230
      • 6: 75830
      • 7: 75744
      • 8: 76685
      • 9: 76562
      • 10: 78423
      • 11: 78424
      • 12: 78425
      • 13: a
      Backtrace
      • 13. app/Models/ContentAccess.php:616
      • 14. app/Http/Controllers/IssueController.php:945
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 51269529 and j.to_ip >=51269529 )) and ((j.from_date <= 1745558825 and j.to_date >= 1745558825 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 7258)
      640μsbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:1022
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '78421' order by au.sequence
      320μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '78422' order by au.sequence
      290μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '75166' order by au.sequence
      330μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '77134' order by au.sequence
      300μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '75115' order by au.sequence
      300μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '76230' order by au.sequence
      280μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '75830' order by au.sequence
      280μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '75744' order by au.sequence
      300μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '76685' order by au.sequence
      290μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '76562' order by au.sequence
      290μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '78423' order by au.sequence
      240μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '78424' order by au.sequence
      240μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '78425' order by au.sequence
      280μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 639 limit 1
      260μsbetabenthamscien_newMeta.php#59
      Bindings
      • 0: 639
      Backtrace
      • 14. app/Models/Meta.php:59
      • 15. app/Http/Controllers/IssueController.php:1181
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 62 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      24.49msbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1188
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues from journal j join volume v on j.journal_id = v.journal_id join year y on v.year_id = y.id where j.journal_id = 62 and y.year = 2025 order by v.volume_name+0 desc limit 1
      420μsbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1189
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 62 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      33.01msbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1191
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      780μsbetabenthamscien_newArticle.php#1959
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1959
      • 14. app/Http/Controllers/IssueController.php:1197
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 62 and `b`.`banner_from_date` <= 1745558825 and `b`.`banner_to_date` >= 1745558825 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      2.27msbetabenthamscien_newBanner.php#189
      Bindings
      • 0: 1
      • 1: J
      • 2: 62
      • 3: 1745558825
      • 4: 1745558825
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='c947c0e75f3a7c9dac159534a398d7f1'
      250μsbetabenthamscien_newCart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
        _token
        JV4f1EyValVMer3YTfJOdgK1EM1HfZK7am4bOemI
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/issue/7258/1" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
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        Date ↕MethodURLData
        #12025-04-25 05:27:05GET/issue/7258/11939