This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs

Ever since the association between cancer and thrombosis was reported by Jean-Baptiste Bouillaud in the early 19th century, cancer-associated thrombosis has remained a challenging domain of cancer management. Thrombosis can at times be a lead to cancer diagnosis, while it often complicates medical situations as a coexisting disorder. In this handbook, the contributors have compiled comprehensive information on the subject to provide the reader a comprehensive review of current medical literature and guidelines for cancer-associated thrombosis. Key Features -clinically oriented text for application in healthcare settings -current, evidence-based literature reviews and references -includes guidelines on VTE prophylaxis, heparin effects and more -includes information about special cases Thrombosis in Cancer: A Medical Professional's Guide to Cancer Associated Thrombosis is an informative handbook for a broad range of readers in medicine, including generalists, residents, and graduate-level trainees.

The management of COVID-19 is challenging due to the lack of clear information about the Sars-Cov2 and recommendations for specific treatment regimens. The scale of the pandemic has also exacerbated the situation, with health care systems under stress from the high volume of COVID-19 patients. In Demystifying COVID-19: Understanding the Disease, Its Diagnosis, and Treatment, medical experts explain many aspects about the COVID-19 pandemic, including guidelines to minimize risk of infection, diagnostic methods, treatment, real scenarios in the course of the disease and issues that need attention in specific patient groups. The book equips both general readers and healthcare professionals with key information required to understand COVID-19 and navigate a situation typical to a pandemic. Public health officials who wish to mobilize awareness campaigns for the benefit of the general public can also find value in the comprehensive information presented in this reference.

Gastroenterology and hepatology represent dynamic fields of study and practice in internal medicine, with numerous innovations manifesting over the last 30 years. What is New in Gastroenterology and Hepatology is a reference which presents updates on the latest advances in the aforementioned subspecialties. The book offers a broad range of topics in a structured, clear and comprehensive fashion. Thirty-three chapters provide knowledge on basic medical research and practical applications in the clinic with information contributed by several members of the Romanian Society of Gastroenterology and Hepatology (a medical society with a history of more than 60 years). The contents feature updates on common and rare disorders of the gastrointestinal tract (esophagus, stomach, intestines), pancreas and the liver, as well as new imaging techniques such as video capsule endoscopy and contrast enhanced ultrasound (CEUS). Special topics of recent interest such as the value of gut microbiota in medical interventions and the use of 'omics' technologies for precision medicine, and telemedicine are also included. What is New in Gastroenterology and Hepatology is an informative reference for all medical researchers and healthcare professionals (gastroenterologists, hepatologists, internal medicine physicians, surgeons, oncologists) who wish to keep themselves up to speed on new advances in these medical subspecialties.

Histopathological Diagnosis of Leprosy, is a comprehensive guide to the medical pathology of Hansen’s disease, which is a complex and clinically challenging infection caused by Mycobacterium leprae. Readers will find 8 chapters on key topics on the subject including general aspects of leprosy, different forms of leprosy (polar, borderline, etc.), reaction types and complications. The information presented in the handbook will equip the reader with the knowledge required to identify the disease in patients and perform differential diagnosis where required. Key Features: - 8 chapters dedicated to key topics about leprosy and its diagnosis - More than 2014 figures featuring over 1000 clinical and histopathological photographs - Complete information about differential diagnosis and reaction phenomena - includes a section dedicated to special and complicated cases - References for further reading - Brings the expertise of renowned physicians to the reader The detailed presentation of the book is of great value to both healthcare professionals (pathologists, dermatologists, physicians) who are involved in the care of leprosy patients, and medical residents who are seeking information about the disease as part of their medical training.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. The seventh volume of the book features reviews on these topics: </P> · Essential oils and monoterpenes as potential anti-cancer agents </P> · Drug delivery systems and emerging immunotherapeutic strategies for the treatment of glioblastoma </P> · CTDNA in solid tumors </P> · Cholesterol treatments (including Pitavastatin) and their potential in cancer treatment

This reference comprehensively covers the clinical aspects of head and neck neoplasms while also highlighting the relationship that exists between inflammation and these cancers. This relationship is critical as it dictates the risks, assessment, treatment, and prognosis of head and neck cancer patients. The book starts with an introduction to the inflammation ecosystem in head and neck malignancy, followed by detailed discussions on the types of head and neck malignancy and their histological classification. The book then provides information about specialized topics relevant to the specialty of head and neck oncology. Key Features: - Comprehensive coverage of head and neck cancers with topic-based chapters - Introductory text explaining the basics of inflammation - Detailed information on the relationship between inflammation and head and neck neoplasms - Information about the classification of head and neck cancers - Methods for diagnosis and treatment - Special topics such as complications caused by HPV infections, chemoradiation, immune-targeted therapy, and inflammatory biomarkers - References for further reading The combination of basic and advanced topics makes this book an informative reference for medical students and professionals at all levels. Residents specializing in otolaryngology, oncology, and surgery as well as researchers studying inflammation will also gain an understanding of the subject in relation to oncogenesis.

In this difficult period of the SARS-CoV-2 (and its variants) infection responsible for Covid-19 diseases, the importance of scientific works and reviews dealing with these viruses has never been more essential and vital. Reports as of 20th April 2021 indicate over 141 million cases of SARS-CoV-2 infection worldwide (with over 3 million deaths recorded). This volume brings together essential data regarding prevention (vaccination), detection, and various approaches (chemotherapeutic drugs and antibodies) to the potential treatment of coronavirus infections. It presents six chapters concerning the following topics: (1) the resistance to the spread of SARS-CoV-2 and related Covid-19 diseases within a population based on the pre-existing immunity of a high proportion of individuals as a result infection or previous vaccination (2) the impact of the Covid-19 pandemic for the South Asian Association for Regional Cooperation (SAARC) region, comprising the Bangladesh, Bhutan, Maldives, Nepal, Pakistan, Sri Lanka, India, and Afghanistan (3) the effect of candidate drugs chloroquine and hydroxychloroquine on QT interval in infected patients with Covid-19 diseases (4) the antiviral potential of herbal-based immunomodulators (5) the humoral immune response in humans based on anti-SARS-CoV-2 antibodies to treat Covid-19 diseases (6) the various methods and strategies for diagnosing SARS-CoV-2 (and its variants) infection in hosts/humans. This compilation should prove to be a tool of crucial importance for researchers around the world working on research revolving around coronaviruses, as well as for clinicians confronted by a growing number of patients with COVID-19. [Series Introduction] Coronaviruses presents compilations of reviews which present information about coronaviridae. Volumes in the series present interesting data on the virology, molecular biology, pathogenesis and epidemiology of these viruses. Current topics such as SARS-CoV-2 infection, COVID-19 epidemiology, economic impact of COVID-19, and new coronavirus variants are also included. The series should prove to be an essential resource on this group of viruses for multidisciplinary researchers and healthcare professionals alike.

COVID-19: Current Challenges and Future Perspectives informs readers about the current status of knowledge on COVID-19 infection. The book begins by presenting basic information about the history, epidemiology, pathogenesis, diagnosis, treatment and preventive measures against COVID-19. The second part of the book contains information about the repurposing of drugs, herbal medicines, and immunotherapy against COVID-19 infections. Integrating both general and advanced information about Sars-cov-2, this book updates a wide range of readers including students, researchers (virologists, pharmacologists), health care professionals (physicians, nurses, pharmacists, paramedics) and the general public on novel coronaviruses and COVID-19.

This monograph presents information about the history and evolution of tuberculosis treatment, and the potential of the benzothiazole moiety for anti-tuberculosis (anti-TB) activity. The book introduces the reader to basic information about benzothiazole as a drug candidate before delving into the anti-tubercular properties of derivative compounds in subsequent chapters. The contributors explain quantitative structural-activity relationships of benzothiazole with anti-TB activity along with the importance of in-silico (computer aided) techniques in the drug design process. This is followed by a chapter which details Mycobacterium tuberculosis biology, strains as well as symptoms of tuberculosis infections. The book then explains in-vitro and in-vivo methods used to evaluate drug efficacy against tuberculosis along with the synthesis and anti-TB activity of the benzothiazole derivatives (benzothiazole diamide, benzothiazole guanidinyl derivatives and benzothiazole conjugated pyrazole derivatives). This book, therefore, is a quick reference on TB diseases, methods of in-silico and in-vitro screening of anti-TB drugs and the importance of the benzothiazole in TB treatment regimens. The book is suitable for readers, researchers and post graduate students who are interested in general tuberculosis drug design, screening and discovery, as well as the application of benzothiazole as an anti-TB drug.