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Current Topics in Medicinal Chemistry

Author(s): Roberta Jeane Bezerra Jorge, René Duarte Martins, Renata Mendonça Araújo, Meykson Alexandre da Silva, Helena Serra Azul Monteiro and Rafael Matos Ximenes*

DOI: 10.2174/1568026619666190723153925

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Plants and Phytocompounds Active Against Bothrops Venoms

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Abstract

Snakebite envenomation is an important health problem in tropical countries, with severe human and social consequences. In Latin America, the Bothrops species constitute the main threat to humans, and the envenomation caused by these species quickly develops into severe local tissue damage, including swelling, hemorrhaging, myonecrosis, skin ulceration, and pain. The systemic effects of envenomation are usually neutralized by antivenom serum therapy, despite its intrinsic risks. However, neutralization of local tissue damage remains a challenge. To improve actual therapy, two major alternatives are proposed: the rational design of new specific antibodies for most of the tissue damaging/ poor immunogenic toxins, or the search for new synthetic or natural compounds which are able to inhibit these toxins and complement the serum therapy. Natural compounds isolated from plants, mainly from those used in folk medicine to treat snakebite, are a good choice for finding new lead compounds to improve snakebite treatment and minimize its consequences for the victims. In this article, we reviewed the most promising plants and phytocompounds active against bothropic venoms.

Keywords: Bothrops, Snakebite envenomation, Medicinal plants, Natural inhibitors, Secondary metabolites, Anti-bothropic serum.

Graphical Abstract

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