Author(s): Enrique Reyes-Muñoz, Federica Di Guardo*, Michal Ciebiera , Ilker Kahramanoglu , Thozhukat Sathyapalan, Li-Te Lin, Mohsin Shah, Erbil Karaman, Shangrong Fan, Gabriella Zito and Marco Noventa
Page: [2467 - 2473] Pages: 7
* (Excluding Mailing and Handling)
Background: Gestational Diabetes Mellitus (GDM), defined as glucose intolerance with onset or first recognition during pregnancy, represents one of the most common maternal-fetal complications during pregnancy and it is associated with poor perinatal outcomes. To date, GDM is a rising condition over the last decades coinciding with the ongoing epidemic of obesity and Type 2 Diabetes Mellitus (T2DM).
Objective: The aim of this review is to discuss the role of diet and nutritional interventions in preventing GDM with the explanation of the special role of myo-inositol (MI) in this matter.
Methods: We performed an overview of the most recent literature data on the subject with particular attention to the effectiveness of diet and nutritional interventions in the prevention of GDM with the special role of MI.
Results: Nutritional intervention and physical activity before and during pregnancy are mandatory in women affected by GDM. Moreover, the availability of insulin-sensitizers such as different forms of inositol has dramatically changed the scenario, allowing the treatment of several metabolic diseases, such as those related to glucose dysbalance. Although the optimal dose, frequency, and form of MI administration need to be further investigated, diet supplementation with MI appears to be an attractive alternative for the GDM prevention as well as for the reduction of GDM-related complications.
Conclusions: More studies should be conducted to prove the most effective nutritional intervention in GDM. Regarding the potential effectiveness of MI, further evidence in multicenter, randomized controlled trials is needed to draw firm conclusions.
Keywords: Gestational diabetes mellitus, metabolic diseases, diet, nutrition, myo-inositol, prevention, management.
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CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 59850559 and j.to_ip >=59850559 )) and ((j.from_date <= 1744718538 and j.to_date >= 1744718538 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 99835)| Backtrace |
|
select * from `article` where `first_page` < '2467' and is_uploaded = 1 and issue_id = 9311 order by cast(first_page as SIGNED) desc limit 1| Bindings |
|
| Backtrace |
|
select * from `article` where `last_page` > '2473' and is_uploaded = 1 and issue_id = 9311 order by cast(first_page as SIGNED) asc limit 1| Bindings |
|
| Backtrace |
|
select `language_id` from `multilanguage` where `short_code` = 'en'| Bindings |
|
| Backtrace |
|
select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1| Bindings |
|
| Backtrace |
|
select `id` from `multilanguage_article` where `article_id` = 99835 limit 1| Bindings |
|
| Backtrace |
|
select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 29 and `b`.`banner_from_date` <= 1744718538 and `b`.`banner_to_date` >= 1744718538 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc| Bindings |
|
| Backtrace |
|
select count(*) as aggregate from `uc_cart_products` where cart_id='fdcdf52df1f72236e177a6a5ffd41aae'| Backtrace |
|
200
[]
[]
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