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Current Pharmaceutical Design

Author(s): Melek Kechida*

DOI: 10.2174/1381612825666190709205421

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Update on Autoimmune Diseases Pathogenesis

Page: [2947 - 2952] Pages: 6

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Abstract

Background: Autoimmune diseases result from the interplay of cellular effectors like T and B cells, regulatory cells in addition to molecular factors like cytokines and regulatory molecules.

Methods: Different electronic databases were searched in a non-systematic way to find out the literature of interest.

Results: Pathogenesis of autoimmune diseases involves typical factors such as genetic background including HLA and non HLA system genes, environmental factors such as infectious agents and inflammatory cells mainly T and B lymphocytes abnormally activated leading to immune dysfunction. Other recently reported less typical factors such as micro-RNAs, circular RNAs, myeloperoxidase, vimentine and microbiome dysbiosis seem to be potential target therapies.

Conclusion: We aimed in this manuscript to review common factors in the pathogenesis of autoimmune diseases.

Keywords: Autoimmune diseases, inflammation, pathogenesis, infectious agents, micro-RNAs, myeloperoxidase.

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