Abstract
Wound tissue repair is a complex and dynamic process of restoring cellular structures and tissue layers.
Improvement in this process is necessary to effectively treat several pathologies characterized by a chronic delayed
wound closure, such as in diabetes, and the investigation of new approaches aimed to ameliorate the wound
healing process is under continuous evolution. Recently, the usage of vegetable matrices in the form of ozonated
oils has been proposed, and several researchers have shown positive effects on wound healing, due to the bactericidal,
antiviral, and antifungal properties of these ozonated oils.
In the present review, we intend to summarize the actual state of the art of the topical usage of ozonated oil in
cutaneous wounds with special emphasis to the importance of the ozonated degree of the oil.
Keywords:
Cutaneous wound healing, ROS, peroxidation, topical application, ozonated oil, inflammation.
[11]
Strbo N, Yin N, Stojadinovic O. Innate and Adaptive Immune Responses in Wound Epithelialization. Adv Wound Care (New Rochelle) 2014; 3(7): 492-501.
[21]
Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen 2008; 16(5): 585-601.
[57]
Horsfall L, Macdonald G, Scott I, et al. Use of standardised assessment forms in referrals to hepatology outpatient services: implications for accurate triaging of patients with chronic hepatitis C. Aust Health Rev 2013; 37(2): 218-22.
[70]
Liu SH, Xie WG, Kremer M, Machens HG, Lankenau EM, Huettmann G. Diagnosis of the deep partial-thickness burn wound of Skh-1 mouse with Optical Coherence Tomography. Zhonghua Shao Shang Za Zhi 2010; 26(4): 272-5.
[83]
Wilhelm KP, Wilhelm D, Bielfeldt S. Models of wound healing: an emphasis on clinical studies. Int Soc Skin Imag 2017; 23(1): 3-12.
[93]
John P. Sundberg LBN, Philip Fleckman, Lloyd E King 23 - Skin and Adnexa. Academic Press 2012; pp. 433-55.
[110]
Gao Y, Wang X, Chen S, Li S, Liu X. Acute skin barrier disruption with repeated tape stripping: an in vivo model for damage skin barrier. Skin Res Technol 2013; 19(2): 162-8.
[111]
Lademann J, Jacobi U, Surber C, Weigmann HJ, Fluhr JW. The tape stripping procedure-evaluation of some critical parameters. Eur J Pharm Biopharm 2009; 72(2): 317-23.
[124]
Fenton HJH. M.A. LXXIII.—Oxidation of tartaric acid in presence of iron. J Chem Soc Trans 1925; 127: 1-36.
[134]
Marrocco I, Altieri F. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxid Med Cell Longev 2017; 20176501046
[170]
Georg Cronheim. Organic ozonides as chemotherapeutic agents. II. Antiseptic properties. J Am Pharma Assoc Ban 1987; 36(9): 278-81.