Author(s): András Keglevich, Vivian Zsiros, Péter Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Erzsébet Mernyák, János Wölfling and László Hazai*
Page: [959 - 967] Pages: 9
* (Excluding Mailing and Handling)
10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.
Keywords: Vinca alkaloids, vindoline, steroid, succinate linker, hybrid molecules, antitumor activity.
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