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Infectious Disorders - Drug Targets

Author(s): Suresh Antony*, Ismail Khan, Omer Chowdhury, Jacob Heydemann, Nishaal Antony, John Heydemann and David Isaac

DOI: 10.2174/1871526519666190613121936

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Proposed Guidelines for the Management of ESBL in Prosthetic Joint Infections

Page: [563 - 569] Pages: 7

  • * (Excluding Mailing and Handling)

Abstract

The aim of this paper is to establish guidelines for the management of extendedspectrum beta-lactamases (ESBL) associated prosthetic joint infections (PJI). This study reviewed 21 patients in the literature documented with ESBL associated PJI. Literature suggests that patients with ESBL PJI are stratified into either early infections (<3 weeks) or late infections (>3 weeks), for which, appropriate laboratory and imaging studies need to be completed. Favorable outcomes require a two-stage revision with an antibiotic-impregnated spacer and a prolonged course of intravenous carbapenem antibiotic.

Keywords: Extended-spectrum beta-lactamases, prosthetic joint infections, infections, intravenous, carbapenem, antibiotic.

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