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Endocrine, Metabolic & Immune Disorders - Drug Targets

Author(s): Katia C. Oliveira, Rita Cardoso, Antonio C. Dos Santos, Ruben Fernandes and Monica C. Botelho*

DOI: 10.2174/1871530319666190529121204

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Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Page: [1122 - 1126] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host.

Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters.

Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls.

Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system.

Keywords: Steroid hormones, Schistosoma mansoni infection, host-parasite interaction, estradiol, testosterone, progesterone, infertility.

Graphical Abstract

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