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Endocrine, Metabolic & Immune Disorders - Drug Targets

Author(s): Seyedeh H. Sharami, Mahboobeh Gholipour, Forozan Milani, Ehsan Kazemnejad, Seyedeh F.D. Heirati and Zahra A. Ranjbar*

DOI: 10.2174/1871530319666190529090517

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The Association between Dyslipidemia and Preterm Birth: A Prospective Cohort Study in The North of Iran

Page: [227 - 233] Pages: 7

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Abstract

Background: Dyslipidemia is recognized as an important factor in the incidence of Preterm Birth (PTB). The early diagnosis of factors affecting PTB is important in the reduction of maternalneonatal complications; therefore, we aimed to evaluate the association between dyslipidemia and PTB in women from the Guilan province of Iran.

Methods: The current investigation was a prospective cohort study on 378 pregnant women in Rasht city (Guilan province), during 2018-2019. Samples were randomly selected among pregnant women who referred to Al-Zahra hospital. Association of the lipid profiles: Total Cholesterol (TC), High- Density Lipoprotein (HDLC), Low-Density Lipoprotein (LDLC), and Triglycerides (TG) with PTB was assessed using the Chi-square, Fisher tests and logistic regression analysis.

Results: Our findings showed that of the evaluated lipid profiles, TG and TC had the highest predictive power with AUC =0.833 (95٪, CI: 0.736-0.930) and 0.772 (95%, CI: 0.676-0.867), respectively; also, their sensitivity and specificity were 83.3%, 70.2% and 83.3%, 66.1%, respectively. Moreover, abnormal LDL concentrations increase the risk of PTB by two folds (P < 0.05).

Conclusion: It seems that by controlling the lipid profiles of pregnant women, the risk of PTB could be reduced.

Keywords: Dyslipidemia, preterm birth, women, pregnancy, triglycerides, Iran, prospective cohort study.

Graphical Abstract

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