[1]
Grassi M, Petraccia L, Mennuni G, Stephen DW, Prashanthi V, Val JL, et al. Changes, functional disorders, and diseases in the gastrointestinal tract of elderly. Nutr Hosp 2011; 26: 559-67.
[2]
Amarya S, Singh K, Sabharwal M. Changes during aging and their association with malnutrition. J Nutr Gerontol Geriatr 2015; 6: 78-84.
[3]
World Population Ageing . 2015. United Nation, New York
[4]
World Population Prospects. The 2017 Revision. Key Findings and Advanced Tables, United Nation, New York 2017.
[5]
Jin K. Modern biological theories of aging. Aging Dis 2010; 1: 72.
[6]
Wyka J, Biernat J, Mikołajczak J, Piotrowska E. Assessment of dietary intake and nutritional status (MNA) in Polish free-living elderly people from rural environments. Arch Gerontol Geriatr 2012; 54: 44-9.
[7]
Sanford AM. Anorexia of aging and its role for frailty. Curr Opin Clin Nutr Metab Care 2017; 20: 54-60.
[8]
Theou O, Cann L, Blodgett J, Wallace LM, Brothers TD, Rockwood K. Modifications to the frailty phenotype criteria: Systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe. Ageing Res Rev 2015; 21: 78-94.
[9]
Campitelli MA, Bronskill SE, Hogan DB, Christina D, Joseph EA, Sudeep G, et al. The prevalence and health consequences of frailty in a population-based older home care cohort: a comparison of different measures. BMC Geriatr 2016; 16: 1-10.
[10]
Visvanathan R. Anorexia of aging. Clin Geriatr Med 2015; 31: 417-27.
[11]
Doets EL, Kremer S. The silver sensory experience- A review of senior consumers’ food perception, liking and intake. Food Qual Prefer 2016; 48: 316-32.
[12]
de Boer A, Ter Horst GJ, Lorist MM. Physiological and psychosocial age-related changes associated with reduced food intake in older persons. Ageing Res Rev 2013; 12: 316-28.
[13]
Landi F, Calvani R, Tosato M, Anna MM, Elena O, Giulia S, et al. Anorexia of aging: Risk factors, consequences, and potential treatments. Nutrients 2016; 8: 1-10.
[14]
Martone AM, Onder G, Vetrano DL, Elena O, Matteo T, Emanuele M, et al. Anorexia of aging: A modifiable risk factor for frailty. Nutrients 2013; 5: 4126-33.
[15]
Turner MD, Ship JA. Dry mouth and its effects on the oral health of elderly people. J Am Dent Assoc 2007; 138: S15-20.
[16]
Mocchegiani E, Romeo J, Malavolta M, Laura C, Robertina G, Ligia-Esperanza D, et al. Zinc: Dietary intake and impact of supplementation on immune function in elderly. Age 2013; 35: 839-60.
[17]
Bauer J, Biolo G, Cederholm T, Matteo C, Alfonso JC, John EM, et al. Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 2013; 14: 542-59.
[18]
Breen L, Stokes KA, Churchward-Venne TA, et al. Two weeks of reduced activity decreases leg lean mass and induces “anabolic resistance” of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab 2013; 98: 2604-12.
[19]
Timmerman KL, Dhanani S, Glynn EL, et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr 2012; 95: 1403-12.
[20]
Gaffney‐Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc 2009; 57: 1073-9.
[21]
Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired iron status in aging research. Int J Mol Sci 2012; 13: 2368-86.
[22]
Fairweather-Tait SJ, Wawer AA, Gillings R, Jennings A, Myint PK. Iron status in the elderly. Mech Ageing Dev 2014; 136: 22-8.
[23]
Zhu K, Prince RL. Calcium and bone. Clin Biochem 2012; 45: 936-42.
[24]
Lips P, Bouillon R, Van Schoor NM, Vanderschueren D, Verschueren S, Kuchuk N, et al. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol 2010; 73: 277-85.
[25]
Huskisson E, Maggini S, Ruf M. The influence of micronutrients on cognitive function and performance. J Int Med Res 2007; 35: 1-19.
[26]
Wong CP, Magnusson KR, Ho E. Increased inflammatory response in aged mice is associated with age-related zinc deficiency and zinc transporter dysregulation. J Nutr Biochem 2013; 24: 353-9.
[27]
Barbagallo M, Dominguez LJ. Magnesium and aging. Curr Pharm Des 2010; 16: 832-9.
[28]
Dawson-Hughes B, Mithal A, Bonjour JP, Boonen S, Burckhardt P, Fuleihan GE, et al. IOF position statement: Vitamin D recommendations for older adults. Osteoporos Int 2010; 21: 1151-4.
[29]
Fabian E, Bogner M, Kickinger A, Wagner KH, Elmadfa I. Vitamin status in elderly people in relation to the use of nutritional supplements. J Nutr Health Aging 2012; 16: 206-12.
[30]
Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci 2012; 24: 5-15.
[31]
Sturtzel B, Dietrich A, Wagner KH, Gisinger C, Elmadfa I. The status of vitamins B6, B12, folate, and of homocysteine in geriatric home residents receiving laxatives or dietary fiber. J Nutr Health Aging 2010; 14: 219-23.
[32]
Araújo JR, Martel F, Borges N, Araújo JM, Keating E. Folates and aging: Role in mild cognitive impairment, dementia and depression. Ageing Res Rev 2015; 22: 9-19.
[33]
Kjeldby IK, Fosnes GS, Ligaarden SC, Farup PG. Vitamin B6 deficiency and diseases in elderly people- A study in nursing homes. BMC Geriatr 2013; 13: 1-8.
[34]
Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, et al. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 2010; 11: 391-6.
[35]
Volpi E, Campbell WW, Dwyer JT, Johnson MA, Jensen GL, Morley JE, et al. Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J Gerontol A Biol Sci Med Sci 2012; 68: 677-81.
[36]
Rhodes D, Clemens J, Goldman J, Moshfegh A. What we eat in America, NHANES tables 1-36 US Department of Agriculture. 2010.Agricultural Research Service.
[37]
Baum JI, Kim IY, Wolfe RR. Protein consumption and the elderly: What is the optimal level of intake? Nutrients 2016; 8: 1-9.
[38]
Morley JE. The role of nutrition in the prevention of age-associated diseases Geriatric Nutrition. edited by Morley, J.E., Thomas, D.. CRC Press 2007; pp. 29-44.
[39]
Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, et al. Calcium intake and risk of fracture: systematic review. Br Med J 2015; 351: 1-10.
[40]
Thomas DR. Nutritional Requirement in Older Adults Geriatric Nutrition. edited by Morley, J.E., Thomas, D. R.. CRC Press 2007 a;; pp. 103-22.
[41]
Barnett JB, Dao MC, Hamer DH, Kandel R, Brandeis G, Wu D, et al. Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: A randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2016; 103: 942-51.
[42]
Kim J, Paik HY, Joung H, Woodhouse LR, Li S, King JC. Effect of dietary phytate on zinc homeostasis in young and elderly Korean women. J Am Coll Nutr 2007; 26: 1-9.
[43]
Haase H, Overbeck S, Rink L. Zinc supplementation for the treatment or prevention of disease: Current status and future perspectives. Exp Gerontol 2008; 43: 394-408.
[44]
Intorre F, Polito A, Andriollo-Sanchez M, Azzini E, Raguzzini A, Toti E, et al. Effect of zinc supplementation on vitamin status of middle-aged and older European adults: The ZENITH study. Eur J Clin Nutr 2008; 62: 1215.
[45]
Busti F, Campostrini N, Martinelli N, Girelli D. Iron deficiency in the elderly population, revisited in the hepcidin era. Front Pharmacol 2014; 5: 83.
[46]
Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263-8.
[47]
Patel KV. Epidemiology of anemia in older adults. In Seminars in Hematology 2008; 45: 210-7.
[48]
Andres E, Serraj K, Federici L, Vogel T, Kaltenbach G. Anemia in elderly patients: New insight into an old disorder. Geriatr Gerontol Int 2013; 13: 519-27.
[49]
Herbert V, Shaw S, Jayatilleke E. Vitamin C-driven free radical generation from iron. J Nutr 1996; 126: 1213S-20S.
[50]
Beydoun MA, Shroff MR, Beydoun HA, Zonderman AB. Serum folate, vitamin B-12 and homocysteine and their association with depressive symptoms among US adults. Psychosom Med 2010; 72: 862-73.
[51]
Kennedy DO. B vitamins and the brain: Mechanisms, dose and efficacy- A review. Nutrients 2016; 8: 68.
[52]
Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2008; 89: 693S-6S.
[53]
Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005; 82: 442-50.
[54]
Smith AD, Refsum H. Vitamin B-12 and cognition in the elderly. Am J Clin Nutr 2008; 89: 707S-11S.
[55]
Mazza A. Nutrition and Type II Diabetes Mellitus in Geriatric Patients Geriatric Nutrition. edited by Morley, J.E., Thomas, D.R. CRC Press 2007; pp. 433-40.
[56]
Thomas DR. Management of Protein-Energy Undernutrition in Older Adults Geriatric Nutrition. edited by Morley, J.E., Thomas, D. R. CRC Press.. 2007 b; pp. 267-90.
[57]
Agarwal E, Miller M, Yaxley A, Isenring E. Malnutrition in the elderly: A narrative review. Maturitas 2013; 76: 296-302.
[58]
Hajjar RR. Nutritional Management of Hpertension Geriatric Nutrition. edited by Morley, J.E., Thomas,D. R. CRC Press 2007; pp. 409-20.
[59]
Academy of Nutrition and Dietetics. Food and nutrition for older adults: Promoting health and wellness. J Acad Nutr Diet 2012; 112: 1255-77.
[60]
Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR. Dietary supplements and mortality rate in older women: The Iowa Women’s Health Study. Arch Intern Med 2011; 171: 1625-33.
[61]
Arnarson A, Geirsdottir OG, Ramel A, Briem K, Jonsson PV, Thorsdottir I. Effects of whey proteins and carbohydrates on the efficacy of resistance training in elderly people: Double blind, randomised controlled trial. Eur J Clin Nutr 2013; 67: 1-6.
[62]
de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine‐lowering B‐vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry 2012; 27: 592-600.
[63]
Salovaara K, Tuppurainen M, Kärkkäinen M, Rikkonen T, Sandini L, Sirola J, et al. Effect of vitamin D3 and calcium on fracture risk in 65‐to 71‐year‐old women: A population‐based 3‐year randomized, controlled trial- the OSTPRE‐FPS. J Bone Miner Res 2010; 25: 1487-95.
[64]
Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367: 40-9.
[65]
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, et al. Fall prevention with supplemental and active forms of vitamin D: A meta-analysis of randomised controlled trials. Br Med J 2009 a; 339: b3692.
[66]
Ceglia L, Niramitmahapanya S, da Silva Morais M, et al. A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab 2013; 98: E1927-35.
[67]
Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: A meta-analysis of randomized controlled trials. Arch Intern Med 2009; 169: 551-61. b
[68]
Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. J Amer Med Assoc 2010; 303: 1815-22.
[69]
Muir SW, Montero‐Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: A systematic review and meta‐analysis. J Am Geriatr Soc 2011; 59: 2291-300.
[70]
Janssen HC, Samson MM, Verhaar HJ. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: A randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res 2010; 22: 78-84.
[71]
Karkkainen M, Tuppurainen M, Salovaara K. Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65–71 years: A 3-year randomized population-based trial (OSTPRE-FPS). Osteoporos Int 2010; 21: 2047-55.
[72]
vanWijngaarden JP, Swart KM, Enneman AW, Dhonukshe-Rutten RA, van Dijk SC, Ham AC, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin Nutr 2014; 100: 1578-6.
[73]
Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: The importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial, 2. Am J Clin Nutr 2015; 102: 215-21.
[74]
Walker JG, Mackinnon AJ, Batterham P, Jorm AF, Hickie I, McCarthy A, et al. Mental health literacy, folic acid and vitamin B 12, and physical activity for the prevention of depression in older adults: Randomised controlled trial. Br J Psychiatry 2010; 197: 45-54.
[75]
Smith AD, Smith SM, De Jager CA, Whitbread P, Johnston C, Agacinski G, et al. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: A randomized controlled trial. PLoS One 2010; 5: 1-10.
[76]
Walker JG, Batterham PJ, Mackinnon AJ, Jorm AF, Hickie I, Fenech M, et al. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms- the Beyond Ageing Project: A randomized controlled trial. Am J Clin Nutr 2011; 95: 194-203.
[77]
van der Zwaluw NL, van De Rest O, Tieland M, Adam JJ, Hiddink GJ, van Loon LJ, et al. The impact of protein supplementation on cognitive performance in frail elderly. Eur J Nutr 2014; 53: 803-12.
[78]
Kwok T, Lee J, Law CB, Pan PC, Yung CY, Choi KC, et al. A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people. Clin Nutr 2013; 30: 297-302.
[79]
Almeida OP, Ford AH, Hirani V, Singh V, McCaul K, Flicker L. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: Results from the B-VITAGE randomised, double-blind, placebo-controlled trial. Br J Psychiatry 2014; 205: 450-7.
[80]
Okereke OI, Cook NR, Albert CM, Van Denburgh M, Buring JE, Manson JE. Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women. Br J Psychiatry 2015; 206: 324-31.
[81]
Giacconi R, Simm A, Santos AN, Costarelli L, Malavolta M, Mecocci P, et al. Influence of+ 1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: Effect of zinc supplementation. Genes Nutr 2014; 9: 426.
[82]
Ducros V, Andriollo-Sanchez M, Arnaud J, Meunier N, Laporte F, Hininger-Favier I, et al. Zinc supplementation does not alter plasma homocysteine, vitamin B12 and red blood cell folate concentrations in French elderly subjects. J Trace Elem Med Biol 2009; 23: 15-20.
[83]
Putics A, Vödrös D, Malavolta M, Mocchegiani E, Csermely P, Sőti C. Zinc supplementation boosts the stress response in the elderly: Hsp70 status is linked to zinc availability in peripheral lymphocytes. Exp Gerontol 2008; 43: 452-61.
[84]
Kahmann L, Uciechowski P, Warmuth S. Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res 2008; 11: 227-37.
[85]
Marcellini F, Giuli C, Papa R, Gagliardi C, Dedoussis G, Monti D, et al. Zinc in elderly people: Effects of zinc supplementation on psychological dimensions in dependence of IL-6-174 polymorphism: A Zincage study. Rejuvenation Res 2008; 11: 479-83.
[86]
Sharif R, Thomas P, Zalewski P, Fenech M. Zinc supplementation influences genomic stability biomarkers, antioxidant activity, and zinc transporter genes in an elderly Australian population with low zinc status. Mol Nutr Food Res 2015; 59: 1200-12.
[87]
Rondanelli M, Opizzi A, Antoniello N, Boschi F, Iadarola P, Pasini E, et al. Effect of essential amino acid supplementation on quality of life, amino acid profile and strength in institutionalized elderly patients. Clin Nutr 2011; 30: 571-7.
[88]
Zhu K, Kerr DA, Meng X, Devine A, Solah V, Binns CW, et al. Two-Year Whey protein supplementation did not enhance muscle mass and physical function in well-nourished healthy older postmenopausal women-3. J Nutr 2015; 145: 2520-526.
[89]
Casperson SL, Sheffield-Moore M, Hewlings SJ, Paddon-Jones D. Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Clin Nutr 2012; 31: 512-9.
[90]
Luiking YC, Deutz NE, Memelink RG, Verlaan S, Wolfe RR. Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: A randomized controlled trial. Nutr J 2014; 13: 1-14.
[91]
Ferrando AA, Paddon-Jones D, Hays NP, Kortebein P, Ronsen O, Williams RH, et al. EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. Clin Nutr 2010; 29: 18-23.
[92]
Pennings B, Groen B, de Lange A, Gijsen AP, Zorenc AH, Senden JM, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 2012; 302: 992-9.
[93]
Bauer JM, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: A randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2015; 16: 740-7.
[94]
Kim CO, Lee KR. Preventive effect of protein-energy supplementation on the functional decline of frail older adults with low socioeconomic status: A community-based randomized controlled study. J Gerontol Biol Sci Med Sci 2012; 68: 309-16.
[95]
Verdijk LB, Jonkers RA, Gleeson BG, Beelen M, Meijer K, Savelberg HH, et al. Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men. Am J Clin Nutr 2008; 89: 608-16.
[96]
Kim HK, Suzuki T, Saito K, Yoshida H, Kobayashi H, Kato H, et al. Effects of exercise and amino acid supplementation on body composition and physical function in community‐dwelling elderly Japanese sarcopenic women: A randomized controlled trial. J Am Geriatr Soc 2010; 60: 16-23.
[97]
Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, et al. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 2012; 13: 713-9.
[98]
Chalé A, Cloutier GJ, Hau C, Phillips EM, Dallal GE, Fielding RA. Efficacy of whey protein supplementation on resistance exercise–induced changes in lean mass, muscle strength, and physical function in mobility-limited older adults. J Gerontol A Biol Sci Med Sci 2012; 68: 682-90.
[99]
Leenders M, Verdijk LB, Van der Hoeven L, Van Kranenburg J, Nilwik R, Wodzig WK, et al. Protein supplementation during resistance-type exercise training in the elderly. Med Sci Sports Exerc 2013; 45: 542-52.
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