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Current Drug Targets

Author(s): Hang Hock Shim*, Christopher Ma, Paulo Gustavo Kotze and Remo Panaccione

DOI: 10.2174/1389450120666190515094435

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Pre-operative Exposure to Ustekinumab: A Risk Factor for Postoperative Complications in Crohn's Disease (CD)?

Page: [1369 - 1372] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

Crohn’s disease (CD) is a chronic inflammatory condition of the intestinal tract that is characterised by a relapsing and remitting course. Despite advancements in therapeutic options for CD, a substantial number of patients still require surgery for medically refractory disease or disease-related complications. Given the widespread adoption of biologic therapies for the management of patients with moderate-to-severe CD, a high number of patients are likely to be on biologic therapy at the time of needing intestinal surgery: the safety of biologics in perioperative setting is of great interest. While more clinical data are available for TNF antagonists and vedolizumab, the safety data for ustekinumab, an IL 12/23 inhibitor, is lacking. Here, we review the available data from published literature on the postoperative outcomes for CD patients exposed to ustekinumab perioperatively.

Keywords: Ustekinumab, Crohn's disease, surgery, chronic inflammatory, biologic therapies, vedolizumab.

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